| Gene Symbol |
CUL2
|
| Entrez Gene |
8453
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cullin 2
|
| Other Description |
CUL-2|cullin-2
|
| Swissprots |
Q5T2B6 G3V1S2 B7Z6K8 O00200 Q13617 Q9UNF9 D3DRY6 B3KT95
|
| Accessions |
EAW85922 EAW85924 EAW85925 EAW85926 EAW85927 EAW85928 Q13617 AF126404 AAD23581 AI089201 AK095217 BAG53007 AK294080 BAH11667 AK300491 BAH13294 AK310225 AL832733 BC009591 AAH09591 BC095405 BC110901 AAI10902 DC401811 DC401936 HG502803 HG502804 HG502805 JF432297 ADZ15514 U58088 AAC50545 U83410 AAC51190 XM_011519743 XP_011518045 XM_011519744 XP_011518046 XM_011519745 XP_011518047 XM_011519746 XP_011518048 XM_011519747 XP_011518049 NM_001198777 NP_001185706 NM_001198778 NP_001185707 NM_001198779 NP_001185708 NM_003591 NP_003582
|
| Function |
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). {ECO:0000250}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Renal cell carcinoma
|
![Western Blot: Cullin 2 Overexpression Lysate (Adult Normal) [NBL1-09607] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cullin 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7620_Cullin%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09607-img0002.jpg)