CUL2
| Gene Symbol | CUL2 |
|---|---|
| Entrez Gene | 8453 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | cullin 2 |
| Other Description | CUL-2|cullin-2 |
| Swissprots | Q5T2B6 G3V1S2 B7Z6K8 O00200 Q13617 Q9UNF9 D3DRY6 B3KT95 |
| Accessions | EAW85922 EAW85924 EAW85925 EAW85926 EAW85927 EAW85928 Q13617 AF126404 AAD23581 AI089201 AK095217 BAG53007 AK294080 BAH11667 AK300491 BAH13294 AK310225 AL832733 BC009591 AAH09591 BC095405 BC110901 AAI10902 DC401811 DC401936 HG502803 HG502804 HG502805 JF432297 ADZ15514 U58088 AAC50545 U83410 AAC51190 XM_011519743 XP_011518045 XM_011519744 XP_011518046 XM_011519745 XP_011518047 XM_011519746 XP_011518048 XM_011519747 XP_011518049 NM_001198777 NP_001185706 NM_001198778 NP_001185707 NM_001198779 NP_001185708 NM_003591 NP_003582 |
| Function | Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). {ECO:0000250}. |
| Top Pathways | Ubiquitin mediated proteolysis, Renal cell carcinoma |
CUL-2 CRISPR/Cas9 KO Plasmid (h) - sc-402370 from Santa Cruz Biotechnology
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CUL-2 HDR Plasmid (h) - sc-402370-HDR from Santa Cruz Biotechnology
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CUL-2 Double Nickase Plasmid (h) - sc-402370-NIC from Santa Cruz Biotechnology
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CUL-2 Double Nickase Plasmid (h2) - sc-402370-NIC-2 from Santa Cruz Biotechnology
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CUL-2 CRISPR Activation Plasmid (h) - sc-402370-ACT from Santa Cruz Biotechnology
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CUL-2 CRISPR Activation Plasmid (h2) - sc-402370-ACT-2 from Santa Cruz Biotechnology
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CUL-2 Lentiviral Activation Particles (h) - sc-402370-LAC from Santa Cruz Biotechnology
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CUL-2 Lentiviral Activation Particles (h2) - sc-402370-LAC-2 from Santa Cruz Biotechnology
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CUL-2 siRNA (h) - sc-35128 from Santa Cruz Biotechnology
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CUL-2 shRNA Plasmid (h) - sc-35128-SH from Santa Cruz Biotechnology
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CUL-2 shRNA (h) Lentiviral Particles - sc-35128-V from Santa Cruz Biotechnology
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Cullin 2 RNAi - H00008453-R01 from Novus Biologicals
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MISSION® esiRNA - EHU011741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6773 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6773 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04241 from Sigma-Aldrich
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CUL2 siRNA (Human) - CRH5541 from Cohesion Biosciences
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CUL2 - MBS8227100 from MyBioSource
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Human CUL2 siRNA - orb266043 from Biorbyt
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CUL2 shRNA Plasmid (Human) - CHH5541 from Cohesion Biosciences
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CUL2 miRNA 3'UTR clone - MiUTR3H-05694 from Creative biogene
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