CUL2

Gene Symbol	CUL2
Entrez Gene	8453
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	cullin 2
Other Description	CUL-2\|cullin-2
Swissprots	Q5T2B6 G3V1S2 B7Z6K8 O00200 Q13617 Q9UNF9 D3DRY6 B3KT95
Accessions	EAW85922 EAW85924 EAW85925 EAW85926 EAW85927 EAW85928 Q13617 AF126404 AAD23581 AI089201 AK095217 BAG53007 AK294080 BAH11667 AK300491 BAH13294 AK310225 AL832733 BC009591 AAH09591 BC095405 BC110901 AAI10902 DC401811 DC401936 HG502803 HG502804 HG502805 JF432297 ADZ15514 U58088 AAC50545 U83410 AAC51190 XM_011519743 XP_011518045 XM_011519744 XP_011518046 XM_011519745 XP_011518047 XM_011519746 XP_011518048 XM_011519747 XP_011518049 NM_001198777 NP_001185706 NM_001198778 NP_001185707 NM_001198779 NP_001185708 NM_003591 NP_003582
Function	Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). {ECO:0000250}.
Top Pathways	Ubiquitin mediated proteolysis, Renal cell carcinoma

CUL-2 (C-4) - sc-166506 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CUL-2 (C-4): sc-166506. Western blot analysis of CUL-2 expression in NIH/3T3 whole cell lysate.

CUL-2 (C-20) - sc-8555 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CUL-2 (C-20): sc-8555. Western blot analysis of CUL-2 expression in NIH/3T3 whole cell lysate.

CUL-2 (N-19) - sc-8554 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CUL-2 (N-19): sc-8554. Western blot analysis of CUL-2 expression in NIH/3T3 whole cell lysate.

CUL-2 (H-300) - sc-10781 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CUL-2 (H-300): sc-10781. Western blot analysis of human recombinant CUL-2 fusion protein.

Anti-Cullin 2 antibody - ab133180 from Abcam

Prices	$385.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Cullin 2 antibody (ab133180) at 1/500 dilutionLane 1 : LOVO cell extractLane 2 : LOVO cell extract with synthesized peptide

Anti-Cullin 2 antibody - ab199658 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Cullin 2 antibody (ab199658) at 1/1000 dilution + MDA-MB-231 cell line lysate at 35 µgSecondaryGoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

Anti-Cullin 2 antibody - ab187504 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Cullin 2 antibody (ab187504) at 1/500 dilutionLane 1 : PC3 cell extractLane 2 : K562 cell extractLane 3 : HL60 cell extractLane 4 : 293T cell extractLane 5 : OVCAR3 cell extract

Anti-Cullin 2 antibody - ab85153 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

ab85153, at a 1/100 dilution, staining Cullin 2 in formalin fixed, paraffin embedded human tonsil by Immunohistochemistry.

Anti-Cullin 2 antibody - ab74280 from Abcam

Prices	$376.00
Sizes	500 µl
Host	Rabbit
Clonality	Polyclonal

Staining of formalin-fixed, paraffin-embedded human tonsil tissue using 1/200 ab74280.

Anti-Cullin 2 antibody - ab53052 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Cullin 2 antibody (ab53052) at 1/500 dilutionLane 1 : extracts from LOVO cells, no immunising peptide.Lane 2 : extracts from LOVO cells, immunising peptide present.

Anti-Cullin 2 antibody [EPR3104(2)] - ab166917 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3104(2)

All lanes : Anti-Cullin 2 antibody [EPR3104(2)] (ab166917) at 1/1000 dilutionLane 1 : PC3 cell lysateLane 2 : 293T cell lysateLane 3 : HeLa cell lysateLane 4 : Raji cell lysateLysates/proteins at 10 µg per lane.

Anti-Cullin 2 antibody, prediluted - ab15194 from Abcam

Prices	$376.00
Sizes	7 ml
Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody (C-Terminus) - LS-C6256 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody - LS-C63984 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody (aa733-745) - LS-C90296 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody (C-Terminus) - LS-C128430 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody (C-Terminus) - LS-C188946 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody (aa149-179, AP) - LS-C208705 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody (Internal) - LS-C137117 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody (C-Terminus) - LS-C112295 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

CUL2 / Cullin 2 antibody LS-C112295 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-CUL2 / Cullin 2 Antibody (aa149-179, APC) - LS-C208706 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody (aa149-179, FITC) - LS-C208708 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody (aa149-179, Biotin) - LS-C208707 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody (aa149-179, Azide-free, HRP) - LS-C208709 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUL2 / Cullin 2 Antibody (aa149-179, PE) - LS-C208710 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Search more