UFD1L

Gene Symbol	UFD1L
Entrez Gene	7353
Alt Symbol	UFD1
Species	Human
Gene Type	protein-coding
Description	ubiquitin fusion degradation 1 like (yeast)
Other Description	UB fusion protein 1|ubiquitin fusion degradation protein 1 homolog
Swissprots	Q92890 Q9Y5N0 A8MW31
Accessions	EAX03037 EAX03038 Q92890 AF141201 AAD28788 AJ239058 CAC20414 AK128120 AK225877 AK304734 BAG65495 AK308786 AK310950 AK315998 BAH14369 AM392868 CAL37746 AW131352 AY101594 AAM48288 BC001049 AAH01049 BC005087 AAH05087 BM761958 BX648374 BX648483 CB128364 CR456607 CAG30493 CU013203 CAK54634 CU013491 CAK54933 DB496066 DB570679 U64444 AAD08720 XM_005261277 XP_005261334 XM_006724319 XP_006724382 XM_011530361 XP_011528663 XM_011530362 XP_011528664 XM_011530363 XP_011528665 NM_001035247 NP_001030324 NM_005659 NP_005650
Function	Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
Tissue Specificity	Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UFD1L full length protein - ab159772 from Abcam Category Protein Source Wheat germ Species Human

Human UFD1L full length protein - ab167871 from Abcam Category Protein Source E. coli Species Human

Human UFD1L protein fragment - ab159773 from Abcam Category Protein Source Wheat germ Species Human

UFD1L Antibody Blocking Peptide - LS-E21738 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UFD1L Partial Recombinant Protein - H00007353-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UFD1L Recombinant Protein - H00007353-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human UFD1L Protein - NBP2-22920 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

UFD1L Protein - GTX109579-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Human UFD1L protein - orb191328 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E. coli Species Human

UFD1L protein (His tag) - 80R-2947 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

UFD1L (1-307, His-tag) - AR51065PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

UFD1L (1-307, His-tag) - AR51065PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

UFD1L - H00007353-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UFD1L - H00007353-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UFD1L - H00007353-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UFD1L - H00007353-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UFD1L Control Peptide - AP10367CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

UFD1L, 1-307aa, Human, His tag, E.coli - 01-P2241 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

UFD1L fusion protein - Ag0954 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human UFD1L, His-tagged - UFD1L-15885H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Ubiquitin fusion degradation protein 1 homolog(UFD1L) - CSB-YP842166HU CSB-EP842166HU CSB-BP842166HU CSB-MP842166HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

uFD1L, 1-307aa, Human, His tag, E.coli - ATGP2241 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

UFD1L (transcript variant 1) - TP302989 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

UFD1L (transcript variant 2) - TP313180 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

UFD1L Recombinant Protein Antigen - NBP1-86879PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

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