| Gene Symbol | UFD1L |
|---|---|
| Entrez Gene | 7353 |
| Alt Symbol | UFD1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin fusion degradation 1 like (yeast) |
| Other Description | UB fusion protein 1|ubiquitin fusion degradation protein 1 homolog |
| Swissprots | Q92890 Q9Y5N0 A8MW31 |
| Accessions | EAX03037 EAX03038 Q92890 AF141201 AAD28788 AJ239058 CAC20414 AK128120 AK225877 AK304734 BAG65495 AK308786 AK310950 AK315998 BAH14369 AM392868 CAL37746 AW131352 AY101594 AAM48288 BC001049 AAH01049 BC005087 AAH05087 BM761958 BX648374 BX648483 CB128364 CR456607 CAG30493 CU013203 CAK54634 CU013491 CAK54933 DB496066 DB570679 U64444 AAD08720 XM_005261277 XP_005261334 XM_006724319 XP_006724382 XM_011530361 XP_011528663 XM_011530362 XP_011528664 XM_011530363 XP_011528665 NM_001035247 NP_001030324 NM_005659 NP_005650 |
| Function | Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. |
| Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. |
| Tissue Specificity | Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney. |
| Top Pathways | Protein processing in endoplasmic reticulum |
UFD1 CRISPR/Cas9 KO Plasmid (h) - sc-403304 from Santa Cruz Biotechnology
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UFD1 HDR Plasmid (h) - sc-403304-HDR from Santa Cruz Biotechnology
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UFD1 Double Nickase Plasmid (h) - sc-403304-NIC from Santa Cruz Biotechnology
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UFD1 Double Nickase Plasmid (h2) - sc-403304-NIC-2 from Santa Cruz Biotechnology
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UFD1 CRISPR Activation Plasmid (h) - sc-403304-ACT from Santa Cruz Biotechnology
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UFD1 CRISPR Activation Plasmid (h2) - sc-403304-ACT-2 from Santa Cruz Biotechnology
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UFD1 Lentiviral Activation Particles (h) - sc-403304-LAC from Santa Cruz Biotechnology
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UFD1 Lentiviral Activation Particles (h2) - sc-403304-LAC-2 from Santa Cruz Biotechnology
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UFD1 siRNA (h) - sc-41689 from Santa Cruz Biotechnology
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UFD1 shRNA Plasmid (h) - sc-41689-SH from Santa Cruz Biotechnology
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UFD1 shRNA (h) Lentiviral Particles - sc-41689-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU078071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22447 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22447 from Sigma-Aldrich
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UFD1L siRNA (Human) - CRH5028 from Cohesion Biosciences
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UFD1L - MBS8235422 from MyBioSource
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shRNA set against Human UFD1L (NM_005659.6) - SHH439932 from Creative biogene
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Human UFD1L siRNA - orb265530 from Biorbyt
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UFD1L shRNA Plasmid (Human) - CHH5028 from Cohesion Biosciences
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UFD1L miRNA 3'UTR clone - MiUTR3H-04385 from Creative biogene
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UFD1L miRNA 3'UTR clone - MiUTR3H-04386 from Creative biogene
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