HSD17B10

Gene Symbol	HSD17B10
Entrez Gene	3028
Alt Symbol	17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1
Species	Human
Gene Type	protein-coding
Description	hydroxysteroid (17-beta) dehydrogenase 10
Other Description	3-hydroxy-2-methylbutyryl-CoA dehydrogenase|3-hydroxyacyl-CoA dehydrogenase type-2|AB-binding alcohol dehydrogenase|amyloid-beta peptide binding alcohol dehydrogenase|endoplasmic reticulum-associated amyloid beta-peptide-binding protein|mitochondrial RNase P subunit 2|mitochondrial ribonuclease P protein 2|short chain L-3-hydroxyacyl-CoA dehydrogenase type 2|short chain dehydrogenase/reductase family 5C member 1|short chain dehydrogenase/reductase family 5C, member 1|short chain type dehydrogenase/reductase XH98G2
Swissprots	Q8TCV9 Q5H927 Q6IBS9 Q99714 Q96HD5
Accessions	AAC16419 ABC70292 CAI42651 CAI42652 CAI42653 EAW93157 EAW93158 EAW93159 Q99714 AF035555 AAC15902 AF069134 AAC39900 AU132847 AY092415 AAM18189 BC000372 AAH00372 BC000829 BC008708 AAH08708 CR456723 CAG33004 JF432473 ADZ15690 U73514 AAB68958 U96132 AAC51812 NM_001037811 NP_001032900 NM_004493 NP_004484
Function	Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). {ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:9338779}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18984158}.
Tissue Specificity	Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD. {ECO:0000269|PubMed:9338779}.
Top Pathways	Alzheimer's disease, Valine, leucine and isoleucine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat HSD17B10 / HADH2 ELISA Kit (Cell-Based ELISA) - LS-F1972 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse HSD17B10 / HADH2 ELISA Kit (Sandwich ELISA) - LS-F8961 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.063 ng/ml Range 0.156-10 ng/ml

Human HSD17B10 / HADH2 ELISA Kit (Sandwich ELISA) - LS-F11610 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10), Human, ELISA Kit - CSB-EL010767HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10), Human, ELISA Kit - E01H1391 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

3-hydroxyacyl-CoA dehydrogenase type-2, HSD17B10, Human, ELISA Kit - E5607h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

hydroxysteroid (17-beta) dehydrogenase 10, ELISA Kit - MBS947121 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 6.25 pg/ml. Range 25 pg/ml-1600 pg/ml.

ERAB Colorimetric Cell-Based ELISA Kit - CB5245 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human HSD17β10(17-Beta-Hydroxysteroid Dehydrogenase Type 10) ELISA Kit - E-EL-H5315 from Elabscience Category ELISA Kit Sensitivity 15.00 pg/mL Range 25.00—1600 pg/mL

HSD17b10, ELISA Kit - MBS2516097 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 15pg/mL Range 25-1600pg/mL

ELISA Kit for 17-Beta-Hydroxysteroid Dehydrogenase Type 10 (HSD17b10) - SEF180Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.063ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human 3-hydroxyacyl-CoA dehydrogenase type-2(HSD17B10) ELISA kit - CSB-EL010767HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Rat HSD17B10 / HADH2 ELISA Kit (Custom ELISA) - LS-F19999 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Bovine HSD17B10 / HADH2 ELISA Kit (Custom ELISA) - LS-F20000 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse HSD17B10 / HADH2 ELISA Kit (Custom ELISA) - LS-F20001 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

3 hydroxyacyl CoA dehydrogenase type 2 (HSD17B10), ELISA Kit - MBS7229337 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Human HSD17b10(17-Beta-Hydroxysteroid Dehydrogenase Type 10) ELISA Kit - E-EL-H5315 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 15 pg/mLpg/mL Range 25~1600 pg/mL

Human 3-hydroxyacyl-CoA dehydrogenase type-2 ELISA Kit - abx251675 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human HSD17B10 / HADH2 ELISA Kit (Sandwich ELISA) - LS-F23378 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 15 pg/ml Range 0.156-10 ng/ml

ERAB ELISA Kit - DEIA-XYA611 from Creative Diagnostics Category ELISA Kit

17-Beta-Hydroxysteroid Dehydrogenase Type 10, HSD17b10, Human, ELISA Kit - E-EL-H5315 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 15 Range 25-1600pg/mL

Human 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) ELISA Kit - EKC32400 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Human 3-hydroxyacyl-CoA dehydrogenase type-2 ELISA Kit - EKE54203 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.087 ng/mL Range 0.156-10 ng/mL

HSD17B10 - EKH4642 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

HSD17B10 ELISA Kit (Human) (OKEH01765) - OKEH01765 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.087 ng/mL Range 0.156 - 10 ng/mL

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