HSD17B10

Gene Symbol	HSD17B10
Entrez Gene	3028
Alt Symbol	17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1
Species	Human
Gene Type	protein-coding
Description	hydroxysteroid (17-beta) dehydrogenase 10
Other Description	3-hydroxy-2-methylbutyryl-CoA dehydrogenase|3-hydroxyacyl-CoA dehydrogenase type-2|AB-binding alcohol dehydrogenase|amyloid-beta peptide binding alcohol dehydrogenase|endoplasmic reticulum-associated amyloid beta-peptide-binding protein|mitochondrial RNase P subunit 2|mitochondrial ribonuclease P protein 2|short chain L-3-hydroxyacyl-CoA dehydrogenase type 2|short chain dehydrogenase/reductase family 5C member 1|short chain dehydrogenase/reductase family 5C, member 1|short chain type dehydrogenase/reductase XH98G2
Swissprots	Q8TCV9 Q5H927 Q6IBS9 Q99714 Q96HD5
Accessions	AAC16419 ABC70292 CAI42651 CAI42652 CAI42653 EAW93157 EAW93158 EAW93159 Q99714 AF035555 AAC15902 AF069134 AAC39900 AU132847 AY092415 AAM18189 BC000372 AAH00372 BC000829 BC008708 AAH08708 CR456723 CAG33004 JF432473 ADZ15690 U73514 AAB68958 U96132 AAC51812 NM_001037811 NP_001032900 NM_004493 NP_004484
Function	Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). {ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:9338779}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18984158}.
Tissue Specificity	Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD. {ECO:0000269|PubMed:9338779}.
Top Pathways	Alzheimer's disease, Valine, leucine and isoleucine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ERAB full length protein - ab85241 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human ERAB full length protein - ab88127 from Abcam Category Protein Source Saccharomyces cerevisiae Species Human

Human ERAB protein fragment - ab93954 from Abcam Category Protein Source E. coli Species Human

HSD17B10 / HADH2 Antibody Blocking Peptide - LS-E25810 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HADH Antibody Blocking Peptide - LS-E19739 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HADH Antibody Blocking Peptide - LS-E19740 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HADH Antibody Blocking Peptide - LS-E26536 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERAB Peptide - NBP2-12541PEP from Novus Biologicals Category Peptide Prices $199.00 Sizes 50 µg Species Human, Mouse, Rat

ERAB Peptide - NBP2-12539PEP from Novus Biologicals Category Peptide Prices $199.00 Sizes 50 µg Species Human, Mouse, Rat

ERAB Recombinant Protein - H00003028-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ERAB Partial Recombinant Protein - H00003028-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ERAB Protein - NBP1-41148 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

ERAB Peptide - P1938 from Novus Biologicals Category Peptide Species Human

ABAD-Antibody-C-term-Blocking-Peptide - BP6307b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ERAB blocking peptide - GTX89602-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

HSD17B10 Protein (OPPA02317) - OPPA02317 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human HSD17B10 protein - orb244939 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Hydroxysteroid (17-beta) Dehydrogenase 10 protein - orb81169 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 25 μg Source E.coli Species Human

Goat anti HSD17B10 antibody Immunizing peptide - orb17903 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

ERAB peptide - orb72658 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

ABAD Blocking Peptide - 33R-10682 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

ERAB Blocking Peptide - 33R-10688 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

HADH protein (His tag) - 80R-1272 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

HSD17B10 protein (His tag) - 80R-1285 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

HADH2 Blocking Peptide - abx062719 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Pig

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