HSD17B10

Gene Symbol	HSD17B10
Entrez Gene	3028
Alt Symbol	17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1
Species	Human
Gene Type	protein-coding
Description	hydroxysteroid (17-beta) dehydrogenase 10
Other Description	3-hydroxy-2-methylbutyryl-CoA dehydrogenase|3-hydroxyacyl-CoA dehydrogenase type-2|AB-binding alcohol dehydrogenase|amyloid-beta peptide binding alcohol dehydrogenase|endoplasmic reticulum-associated amyloid beta-peptide-binding protein|mitochondrial RNase P subunit 2|mitochondrial ribonuclease P protein 2|short chain L-3-hydroxyacyl-CoA dehydrogenase type 2|short chain dehydrogenase/reductase family 5C member 1|short chain dehydrogenase/reductase family 5C, member 1|short chain type dehydrogenase/reductase XH98G2
Swissprots	Q8TCV9 Q5H927 Q6IBS9 Q99714 Q96HD5
Accessions	AAC16419 ABC70292 CAI42651 CAI42652 CAI42653 EAW93157 EAW93158 EAW93159 Q99714 AF035555 AAC15902 AF069134 AAC39900 AU132847 AY092415 AAM18189 BC000372 AAH00372 BC000829 BC008708 AAH08708 CR456723 CAG33004 JF432473 ADZ15690 U73514 AAB68958 U96132 AAC51812 NM_001037811 NP_001032900 NM_004493 NP_004484
Function	Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). {ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:9338779}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18984158}.
Tissue Specificity	Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD. {ECO:0000269|PubMed:9338779}.
Top Pathways	Alzheimer's disease, Valine, leucine and isoleucine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ERAB (E-10) - sc-393693 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

ERAB (F-1) - sc-393694 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

ERAB (23) - sc-136326 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

ERAB (C-20) - sc-7689 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ERAB (H-81) - sc-292620 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

ERAB (K-20) - sc-7690 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ERAB antibody - ab52243 from Abcam Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ERAB antibody - ab137455 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ERAB antibody - ab17297 from Abcam Prices $373.00 Sizes 25 µl Host Rabbit Clonality Polyclonal

Anti-ERAB antibody - ab17298 from Abcam Prices $372.00 Sizes 25 µl Host Rabbit Clonality Polyclonal

Anti-ERAB antibody - ab28750 from Abcam Prices $376.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-ERAB antibody [10D12] - ab10259 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 10D12

Anti-ERAB antibody [5F3] - ab10260 from Abcam Prices $379.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5F3

Anti-ERAB antibody [EPR11838(B)] - ab170864 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR11838(B)

Anti-ERAB antibody [EPR11839(B)] - ab167410 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR11839(B)

Anti-HSD17B10 / HADH2 Antibody - LS-C137425 from LifeSpan Bioscience Prices $265.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-HSD17B10 / HADH2 Antibody - LS-C183438 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B10 / HADH2 Antibody - LS-C183439 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B10 / HADH2 Antibody (aa100-116) - LS-C188979 from LifeSpan Bioscience Prices $425.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B10 / HADH2 Antibody - LS-C308178 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-HSD17B10 / HADH2 Antibody (aa111-160) - LS-C118440 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B10 / HADH2 Antibody - LS-C311211 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B10 / HADH2 Antibody - LS-C341203 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSD17B10 / HADH2 Antibody (aa100-116) - LS-C50250 from LifeSpan Bioscience Prices $530.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-HSD17B10 / HADH2 Antibody (aa253-257) - LS-C205171 from LifeSpan Bioscience Prices $265.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

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