HSD17B10

Gene Symbol HSD17B10
Entrez Gene 3028
Alt Symbol 17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1
Species Human
Gene Type protein-coding
Description hydroxysteroid (17-beta) dehydrogenase 10
Other Description 3-hydroxy-2-methylbutyryl-CoA dehydrogenase|3-hydroxyacyl-CoA dehydrogenase type-2|AB-binding alcohol dehydrogenase|amyloid-beta peptide binding alcohol dehydrogenase|endoplasmic reticulum-associated amyloid beta-peptide-binding protein|mitochondrial RNase P subunit 2|mitochondrial ribonuclease P protein 2|short chain L-3-hydroxyacyl-CoA dehydrogenase type 2|short chain dehydrogenase/reductase family 5C member 1|short chain dehydrogenase/reductase family 5C, member 1|short chain type dehydrogenase/reductase XH98G2
Swissprots Q8TCV9 Q5H927 Q6IBS9 Q99714 Q96HD5
Accessions AAC16419 ABC70292 CAI42651 CAI42652 CAI42653 EAW93157 EAW93158 EAW93159 Q99714 AF035555 AAC15902 AF069134 AAC39900 AU132847 AY092415 AAM18189 BC000372 AAH00372 BC000829 BC008708 AAH08708 CR456723 CAG33004 JF432473 ADZ15690 U73514 AAB68958 U96132 AAC51812 NM_001037811 NP_001032900 NM_004493 NP_004484
Function Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). {ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:9338779}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18984158}.
Tissue Specificity Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD. {ECO:0000269|PubMed:9338779}.
Top Pathways Alzheimer's disease, Valine, leucine and isoleucine degradation

ERAB CRISPR/Cas9 KO Plasmid (h) - sc-405211 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAB HDR Plasmid (h) - sc-405211-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAB Double Nickase Plasmid (h) - sc-405211-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAB Double Nickase Plasmid (h2) - sc-405211-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAB CRISPR Activation Plasmid (h) - sc-405211-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAB CRISPR Activation Plasmid (h2) - sc-405211-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAB Lentiviral Activation Particles (h) - sc-405211-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAB Lentiviral Activation Particles (h2) - sc-405211-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ERAB siRNA (h) - sc-41938 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ERAB shRNA Plasmid (h) - sc-41938-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ERAB shRNA (h) Lentiviral Particles - sc-41938-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ERAB RNAi - H00003028-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU015171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10322 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10322 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HSD17B10 siRNA (Human) - CRH2057 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ERAB RNAi - H00003028-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

HSD17B10 - MBS8235603 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HSD17B10 (NM_004493.2) - SHH315145 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HSD17B10(NM_001037811.2) - SHH132411 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HSD17B10(NM_004493.2) - SHH132429 from Creative biogene

Category siRNA
Species Reactivities Human

HSD17B10 shRNA Plasmid (Human) - CHH2057 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HSD17B10 miRNA 3'UTR clone - MiUTR1H-04712 from Creative biogene

Species Reactivities Human

HSD17B10 miRNA 3'UTR clone - MiUTR1H-04713 from Creative biogene

Species Reactivities Human
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