| Gene Symbol |
FBLN5
|
| Entrez Gene |
10516
|
| Alt Symbol |
ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, UP50
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fibulin 5
|
| Other Description |
developmental arteries and neural crest EGF-like protein|fibulin-5|urine p50 protein
|
| Swissprots |
Q6UWA3 Q6IAL4 O75966 Q9UBX5
|
| Accessions |
CAF86416 CAJ30879 EAW81465 EAW81466 EAW81467 Q9UBX5 AA812956 AF093118 AAC62107 AF112152 AAD41768 AJ133490 CAB38568 AK074540 BAG51970 AK075147 BAG52073 AK094032 AK125600 AK307592 AL110148 AL546863 AY358898 AAQ89257 BC022280 AAH22280 BP338841 BX248290 CAD62618 BX537531 CR457140 CAG33421 DB263961 XM_005267267 XP_005267324 XM_011536356 XP_011534658 XM_011536357 XP_011534659 XM_011536358 XP_011534660 NM_006329 NP_006320
|
| Function |
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). {ECO:0000250|UniProtKB:Q9WVH9, ECO:0000269|PubMed:10428823, ECO:0000269|PubMed:18185537}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:16652333, ECO:0000269|PubMed:17035250, ECO:0000269|PubMed:20599547}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17035250}. Note=co-localizes with ELN in elastic fibers. {ECO:0000269|PubMed:17035250}.
|
| Tissue Specificity |
Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823). {ECO:0000269|PubMed:10428823, ECO:0000269|PubMed:17035250}.
|
![Western Blot: Fibulin 5 Overexpression Lysate (Adult Normal) [NBL1-10609] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Fibulin 5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3715_Fibulin%25205%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10609-img0002.jpg)