FBLN5

Gene Symbol FBLN5
Entrez Gene 10516
Alt Symbol ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, UP50
Species Human
Gene Type protein-coding
Description fibulin 5
Other Description developmental arteries and neural crest EGF-like protein|fibulin-5|urine p50 protein
Swissprots Q6UWA3 Q6IAL4 O75966 Q9UBX5
Accessions CAF86416 CAJ30879 EAW81465 EAW81466 EAW81467 Q9UBX5 AA812956 AF093118 AAC62107 AF112152 AAD41768 AJ133490 CAB38568 AK074540 BAG51970 AK075147 BAG52073 AK094032 AK125600 AK307592 AL110148 AL546863 AY358898 AAQ89257 BC022280 AAH22280 BP338841 BX248290 CAD62618 BX537531 CR457140 CAG33421 DB263961 XM_005267267 XP_005267324 XM_011536356 XP_011534658 XM_011536357 XP_011534659 XM_011536358 XP_011534660 NM_006329 NP_006320
Function Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). {ECO:0000250|UniProtKB:Q9WVH9, ECO:0000269|PubMed:10428823, ECO:0000269|PubMed:18185537}.
Subcellular Location Secreted {ECO:0000269|PubMed:16652333, ECO:0000269|PubMed:17035250, ECO:0000269|PubMed:20599547}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17035250}. Note=co-localizes with ELN in elastic fibers. {ECO:0000269|PubMed:17035250}.
Tissue Specificity Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823). {ECO:0000269|PubMed:10428823, ECO:0000269|PubMed:17035250}.

Fibulin-5 CRISPR/Cas9 KO Plasmid (h) - sc-402597 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibulin-5 HDR Plasmid (h) - sc-402597-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibulin-5 Double Nickase Plasmid (h) - sc-402597-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibulin-5 Double Nickase Plasmid (h2) - sc-402597-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibulin-5 CRISPR Activation Plasmid (h) - sc-402597-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibulin-5 CRISPR Activation Plasmid (h2) - sc-402597-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibulin-5 Lentiviral Activation Particles (h) - sc-402597-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibulin-5 Lentiviral Activation Particles (h2) - sc-402597-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibulin-5 siRNA (h) - sc-43121 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fibulin-5 shRNA Plasmid (h) - sc-43121-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fibulin-5 shRNA (h) Lentiviral Particles - sc-43121-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fibulin 5/DANCE RNAi - H00010516-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU084521 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8506 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8506 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FBLN5 siRNA (Human) - CRH7143 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBLN5 - MBS8222801 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FBLN5 (NM_006329.3) - SHH292713 from Creative biogene

Category siRNA
Species Reactivities Human

FBLN5 shRNA Plasmid (Human) - CHH7143 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FBLN5 miRNA 3'UTR clone - MiUTR3H-06927 from Creative biogene

Species Reactivities Human
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