Gene Symbol | APLN |
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Entrez Gene | 8862 |
Alt Symbol | APEL, XNPEP2 |
Species | Human |
Gene Type | protein-coding |
Description | apelin |
Other Description | AGTRL1 ligand|APJ endogenous ligand |
Swissprots | Q8WU89 Q9ULZ1 Q4VY08 |
Accessions | AAF25815 EAX11828 EAX11829 Q9ULZ1 AB023493 BAA84975 AF086248 AK001855 AK312061 BAG34997 AY358657 AAQ89020 BC021104 AAH21104 BM992527 DB481574 DQ892125 ABM83051 DQ895318 ABM86244 NM_017413 NP_059109 |
Function | Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. {ECO:0000269|PubMed:11090199}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk. |
Apelin (C-13) - sc-33470 from Santa Cruz Biotechnology
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Apelin (FL-77) - sc-33804 from Santa Cruz Biotechnology
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Apelin (M-77) - sc-33805 from Santa Cruz Biotechnology
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Apelin (S-20) - sc-33469 from Santa Cruz Biotechnology
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Anti-Apelin antibody - ab125213 from Abcam
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Anti-Apelin antibody [EPNCIR154] - ab133624 from Abcam
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Anti-Apelin antibody [EPNCIR158] - ab151565 from Abcam
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Anti-Apelin Antibody - LS-C149236 from LifeSpan Bioscience
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Anti-Apelin Antibody - LS-C149235 from LifeSpan Bioscience
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Anti-Apelin Antibody (C-Terminus) - LS-C153380 from LifeSpan Bioscience
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Anti-Apelin Antibody - LS-C149244 from LifeSpan Bioscience
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Anti-Apelin Antibody (aa19-77, Biotin) - LS-C299752 from LifeSpan Bioscience
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Anti-Apelin Antibody (aa24-77, FITC) - LS-C303839 from LifeSpan Bioscience
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Anti-Apelin Antibody (aa19-77, FITC) - LS-C303168 from LifeSpan Bioscience
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Anti-Apelin Antibody (aa24-77, Biotin) - LS-C300858 from LifeSpan Bioscience
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Anti-Apelin Antibody (clone 2A1-2D5) - LS-C306287 from LifeSpan Bioscience
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Anti-Apelin Antibody - LS-C309470 from LifeSpan Bioscience
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Anti-Apelin Antibody - LS-C318516 from LifeSpan Bioscience
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Anti-Apelin Antibody (aa19-77) - LS-C292877 from LifeSpan Bioscience
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Anti-Apelin Antibody (aa24-77) - LS-C292876 from LifeSpan Bioscience
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Anti-Apelin Antibody (C-Terminus, Biotin) - LS-C343568 from LifeSpan Bioscience
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Anti-Apelin Antibody (N-Terminus, Biotin) - LS-C343566 from LifeSpan Bioscience
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Anti-Apelin Antibody (Biotin) - LS-C343576 from LifeSpan Bioscience
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Anti-Apelin Antibody (aa23-77) - LS-C314942 from LifeSpan Bioscience
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Anti-Apelin Antibody (aa60-77) - LS-C312659 from LifeSpan Bioscience
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