| Gene Symbol |
APLN
|
| Entrez Gene |
8862
|
| Alt Symbol |
APEL, XNPEP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apelin
|
| Other Description |
AGTRL1 ligand|APJ endogenous ligand
|
| Swissprots |
Q8WU89 Q9ULZ1 Q4VY08
|
| Accessions |
AAF25815 EAX11828 EAX11829 Q9ULZ1 AB023493 BAA84975 AF086248 AK001855 AK312061 BAG34997 AY358657 AAQ89020 BC021104 AAH21104 BM992527 DB481574 DQ892125 ABM83051 DQ895318 ABM86244 NM_017413 NP_059109
|
| Function |
Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. {ECO:0000269|PubMed:11090199}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk.
|