| Gene Symbol |
RBL2
|
| Entrez Gene |
5934
|
| Alt Symbol |
P130, Rb2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinoblastoma-like 2
|
| Other Description |
130 kDa retinoblastoma-associated protein|PRB2|RBR-2|retinoblastoma-like protein 2|retinoblastoma-related protein 2
|
| Swissprots |
Q15073 B7Z913 Q08999 Q16084 Q92812 Q8NE70
|
| Accessions |
AAC50479 EAW82801 EAW82802 Q08999 AK129969 AK300047 BAG61857 AK304283 BAH14149 AK307881 BC034490 AAH34490 BX537767 CAD97830 DB017942 S67171 AAB29227 X74594 CAA52671 X76061 CAA53661 XM_005256083 XP_005256140 XM_011523252 XP_011521554 XM_011523253 XP_011521555 NM_005611 NP_005602
|
| Function |
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Cell cycle, Viral carcinogenesis, PI3K-Akt signaling pathway
|