RBL2

Gene Symbol RBL2
Entrez Gene 5934
Alt Symbol P130, Rb2
Species Human
Gene Type protein-coding
Description retinoblastoma-like 2
Other Description 130 kDa retinoblastoma-associated protein|PRB2|RBR-2|retinoblastoma-like protein 2|retinoblastoma-related protein 2
Swissprots Q15073 B7Z913 Q08999 Q16084 Q92812 Q8NE70
Accessions AAC50479 EAW82801 EAW82802 Q08999 AK129969 AK300047 BAG61857 AK304283 BAH14149 AK307881 BC034490 AAH34490 BX537767 CAD97830 DB017942 S67171 AAB29227 X74594 CAA52671 X76061 CAA53661 XM_005256083 XP_005256140 XM_011523252 XP_011521554 XM_011523253 XP_011521555 NM_005611 NP_005602
Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Subcellular Location Nucleus.
Top Pathways Cell cycle, Viral carcinogenesis, PI3K-Akt signaling pathway

RBL2 (D9T7M) Rabbit mAb - 13610 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9T7M
Western blot analysis of extracts from various cell lines using RBL2 (D9T7M) Rabbit mAb.

p130 (A-10) - sc-374521 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p130 (A-10): sc-374521. Immunofluorescence staining of methanol-fixed HeLa cells showing nucleolar and nuclear localization.

p130 (211.6) - sc-9963 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p130 (211.6): sc-9963. Western blot analysis of p130 expression in Jurkat (A) and C32 (B) nuclear extracts.

p130 (F-8) - sc-365163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p130 (F-8): sc-365163. Western blot analysis of p130 expression in C32 nuclear extract.

p130 (C-20) - sc-317 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p130 (C-20): sc-317. Western blot analysis of Rb-related p130 expression in Jurkat (A) and C32 (B) nuclear extracts.

p130 (DCS-211) - sc-56176 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p130 (DCS-211): sc-56176. Western blot analysis of p130 expression in Jurkat (A) and C32 (B) nuclear extracts.

p130 (G-15) - sc-31339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p130 (G-15): sc-31339. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing nuclear staining of fibroblasts, keratinocytes, Langerhans cells and melanocytes.

p130 (DCS-215) - sc-53641 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p130 (DCS-215): sc-53641. Western blot analysis of p130 expression in Jurkat whole cell lysate.

p130 (K-17) - sc-31338 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-p130 (Ser 639) - sc-16301 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-p130 (Thr 986) - sc-16299 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-p130 (Thr 986): sc-16299. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing nuclear and cytoplasmic staining of keratinocytes, Langerhans cells and melanocytes.

p-p130 (Ser 952) - sc-22157 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-p130 (Ser 966) - sc-16300 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of p130 phosphorylation in untreated (A) and lambda protein phosphatase (sc-200312A) treated (B) Jurkat whole cell lysates. Antibody tested is p-p130 (Ser 966)-R: sc-16300-R and p130 (A-10): sc-374521.

Anti-p130 (phospho S672) antibody [EP2126Y] - ab76255 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2126Y
All lanes : Anti-p130 (phospho S672) antibody [EP2126Y] (ab76255) at 1/10000 dilutionLane 1 : Jurkat cell lysates, treated with APLane 2 : Jurkat cell lysates, untreatedLysates/proteins at 10 µg/ml per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-p130 antibody - ab89459 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-p130 antibody (ab89459) at 1 µg/ml + 293 cell lysate at 50 µg

Anti-p130 antibody [130P215] - ab80628 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 130P215
Formalin fixed, paraffin embedded human colon cancer stained with anti p130 (a different form of ab80628, containing BSA and azide) at a 1/100 dilution, using peroxidase conjugate and AEC chromogen. Note nuclear staining of tumor cells.

Anti-p130 antibody [EP2141Y] - ab76234 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2141Y
Anti-p130 antibody [EP2141Y] (ab76234) at 1/1000 dilution (unpurified) + Daudi cell lysate at 10 µgSecondaryPeroxidase-conjugated goat anti-rabbit IgG at 1/1000 dilution

Anti-p130 antibody [SPM301], prediluted - ab75694 from Abcam

Prices $376.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone SPM301
ab75694, prediluted, staining p130 in formalin fixed, paraffin embedded human colon cancer tissue sections by Immunohistochemistry.

Anti-Rb2 p130 (phospho S952) antibody [EP2387AY] - ab68136 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2387AY
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab68136 at a dilution of 1/100.

Anti-Rb2 p130 antibody - ab6545 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab6545 staining Rb2 p130 in Mouse lung tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with 4% paraformaldehyde in PBS at 4°C overnight, embedded in paraffin was and section a 7μm. Endogenous enzyme activity was quenched by 2% H2O2 in methanol (30 minutes). Sections were blocked wirh 2% BSA, 5% serum and 0.1% Trition X-100 in PBS. Samples were incubated with primary antibody (1/500 in blocking buffer). White arrow heads mark epithelial cells expressing high levels of protein in nuclear and perinuclear locations.

Anti-Rb2 p130 antibody - ab18577 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Rb2 p130 antibody - ab62643 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells, using ab62643 at a 1/500 dilution. Left image untreated. Right image treated with peptide.

Anti-Rb2 p130 antibody [2C8A8] - ab201943 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C8A8
Anti-Rb2 p130 antibody [2C8A8] (ab201943) at 1/500 dilution + Human Rb2 p130 (aa939-1139) recombinant protein

Anti-Rb2 p130 antibody [KAB40] - ab10576 from Abcam

Host Mouse
Clonality Monoclonal
Clone KAB40

Anti-Rb2 p130 antibody [KAB40] - ab16673 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone KAB40
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