RBL2

Gene Symbol	RBL2
Entrez Gene	5934
Alt Symbol	P130, Rb2
Species	Human
Gene Type	protein-coding
Description	retinoblastoma-like 2
Other Description	130 kDa retinoblastoma-associated protein|PRB2|RBR-2|retinoblastoma-like protein 2|retinoblastoma-related protein 2
Swissprots	Q15073 B7Z913 Q08999 Q16084 Q92812 Q8NE70
Accessions	AAC50479 EAW82801 EAW82802 Q08999 AK129969 AK300047 BAG61857 AK304283 BAH14149 AK307881 BC034490 AAH34490 BX537767 CAD97830 DB017942 S67171 AAB29227 X74594 CAA52671 X76061 CAA53661 XM_005256083 XP_005256140 XM_011523252 XP_011521554 XM_011523253 XP_011521555 NM_005611 NP_005602
Function	Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Subcellular Location	Nucleus.
Top Pathways	Cell cycle, Viral carcinogenesis, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® RBL2 siRNA I - 14712 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

p130 CRISPR/Cas9 KO Plasmid (h) - sc-400721 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p130 HDR Plasmid (h) - sc-400721-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p130 Double Nickase Plasmid (h) - sc-400721-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p130 Double Nickase Plasmid (h2) - sc-400721-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p130 CRISPR Activation Plasmid (h) - sc-400721-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p130 CRISPR Activation Plasmid (h2) - sc-400721-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p130 Lentiviral Activation Particles (h) - sc-400721-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p130 Lentiviral Activation Particles (h2) - sc-400721-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p130 siRNA (h) - sc-29425 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p130 shRNA Plasmid (h) - sc-29425-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p130 shRNA (h) Lentiviral Particles - sc-29425-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PRB2 RNAi - H00440083-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

p130 RNAi - H00005934-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU022731 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2302 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2302 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00047 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00047

RBL2 siRNA (Human) - CRH4020 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RBL2 - MBS8225713 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

p130 CRISPR/Cas9 KO Plasmid (h2) - sc-400721-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p130 HDR Plasmid (h2) - sc-400721-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human RBL2 (NM_005611.3) - SHH390476 from Creative biogene Category siRNA Species Reactivities Human

RBL2 shRNA Plasmid (Human) - CHH4020 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

RBL2 miRNA 3'UTR clone - MiUTR3H-02025 from Creative biogene Species Reactivities Human

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