RBL2

Gene Symbol	RBL2
Entrez Gene	5934
Alt Symbol	P130, Rb2
Species	Human
Gene Type	protein-coding
Description	retinoblastoma-like 2
Other Description	130 kDa retinoblastoma-associated protein|PRB2|RBR-2|retinoblastoma-like protein 2|retinoblastoma-related protein 2
Swissprots	Q15073 B7Z913 Q08999 Q16084 Q92812 Q8NE70
Accessions	AAC50479 EAW82801 EAW82802 Q08999 AK129969 AK300047 BAG61857 AK304283 BAH14149 AK307881 BC034490 AAH34490 BX537767 CAD97830 DB017942 S67171 AAB29227 X74594 CAA52671 X76061 CAA53661 XM_005256083 XP_005256140 XM_011523252 XP_011521554 XM_011523253 XP_011521555 NM_005611 NP_005602
Function	Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Subcellular Location	Nucleus.
Top Pathways	Cell cycle, Viral carcinogenesis, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Rb2 p130 protein fragment - ab159318 from Abcam Category Protein Source Wheat germ Species Human

RBL2 / RB2 p130 Antibody Blocking Peptide - LS-E1503 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RBL2 / RB2 p130 Antibody Blocking Peptide - LS-E13909 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human p130 Protein - H00005934-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RBL2-Antibody-N-term-Blocking-peptide - BP12224a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RB2 Blocking Peptide - abx161206 from Abbexa Category Peptide Species Human, Mouse, Rat

RBL2 / p130 - H00005934-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RBL2 / p130 - H00005934-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RBL2 fusion protein - Ag3377 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human RBL2 protein, MYC/DDK-tagged - RBL2-2483H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant Human RBL2, GST-tagged - RBL2-2205H from Creative Biomart Category Protein Source E.coli Species Human

RB2 Blocking Peptide - CBP3705 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human Retinoblastoma-like protein 2(RBL2) ,partial - CSB-YP600921HU CSB-EP600921HU CSB-BP600921HU CSB-MP600921HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

p130 (406-530) - sc-4405 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

RBL2 / p130 - TP305380 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

p130, Peptide - MBS443045 from MyBioSource Category Peptide Prices $125.00 Sizes 100 µg

p130 Recombinant Protein Antigen - NBP1-82455PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RBL2p130-Antibody-Center-Blocking-Peptide - BP6543c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RBL2p130-Antibody-N-term-Blocking-Peptide - BP6543a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRB2 Peptide, Human - M34GP12338H from Creative Peptides Category Peptide Source Synthetic. Species Human

RBL2 Peptide, Human - M34GP13040H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Retinoblastoma-Like 2 (RBL2), transfected HEK293 cell lysate - 230-10181-100 from RayBiotech Category Protein Prices $135.00 Sizes 100 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Human RBL2, transfected HEK293 cell Lysate - orb385178 from Biorbyt Category Protein Prices $349.00 Sizes 100 μg Species Human

Retinoblastoma-like protein 2 (RBL2), partial, Recombinant Protein - MBS1334927 from MyBioSource Category Protein Prices $950.00, $950.00, $1,170.00, $1,170.00, $1,390.00, $1,390.00, $1,850.00, $1,850.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RBL2 fusion protein - Ag25087 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

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