Gene Symbol | CRB3 |
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Entrez Gene | 92359 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | crumbs family member 3 |
Other Description | crumbs homolog 3|crumbs protein homolog 3|protein crumbs homolog 3 |
Swissprots | Q8N0V8 Q8WVA0 A8KA91 Q9BUF7 D6W643 |
Accessions | EAW69083 EAW69084 EAW69085 EAW69086 Q9BUF7 AF503290 AAM23013 AK000653 AK292956 BAF85645 AY103469 AAM44074 AY358684 AAQ89047 BC002652 AAH02652 BC018409 AAH18409 BM129809 CN403242 XM_005259680 XP_005259737 NM_139161 NP_631900 NM_174881 NP_777377 |
Function | Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. {ECO:0000269|PubMed:12771187, ECO:0000269|PubMed:14718572}. |
Subcellular Location | Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells. |
Tissue Specificity | Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate. {ECO:0000269|PubMed:12527193, ECO:0000269|PubMed:14718572}. |
Top Pathways | Tight junction |
Human CRB3 full length protein - ab164906 from Abcam
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CRB3 Antibody Blocking Peptide - LS-E5135 from LifeSpan Bioscience
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Recombinant Human CRB3 Protein - H00092359-P01 from Novus Biologicals
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CRB3-Antibody-Center-Blocking-Peptide - BP17560c from Abgent, a WuXi AppTec company
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Crumbs homolog 3 - H00092359-P01-10 from Acris Antibodies
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Crumbs homolog 3 - H00092359-P01-25 from Acris Antibodies
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CRB3 fusion protein - Ag2968 from Proteintech Group
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Recombinant Human CRB3, GST-tagged - CRB3-11555H from Creative Biomart
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Recombinant Human Crumbs protein homolog 3(CRB3) - CSB-YP866285HU CSB-EP866285HU CSB-BP866285HU CSB-MP866285HU from Cusabio
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CRB3 Recombinant Protein Antigen - NBP1-81185PEP from Novus Biologicals
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CRB3 Peptide, Human - M34GP03615H from Creative Peptides
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CRB3 fusion protein - Ag26303 from Proteintech Group
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CRB3 fusion protein - Ag25981 from Proteintech Group
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