CRB3

Gene Symbol	CRB3
Entrez Gene	92359
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	crumbs family member 3
Other Description	crumbs homolog 3\|crumbs protein homolog 3\|protein crumbs homolog 3
Swissprots	Q8N0V8 Q8WVA0 A8KA91 Q9BUF7 D6W643
Accessions	EAW69083 EAW69084 EAW69085 EAW69086 Q9BUF7 AF503290 AAM23013 AK000653 AK292956 BAF85645 AY103469 AAM44074 AY358684 AAQ89047 BC002652 AAH02652 BC018409 AAH18409 BM129809 CN403242 XM_005259680 XP_005259737 NM_139161 NP_631900 NM_174881 NP_777377
Function	Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. {ECO:0000269\|PubMed:12771187, ECO:0000269\|PubMed:14718572}.
Subcellular Location	Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.
Tissue Specificity	Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate. {ECO:0000269\|PubMed:12527193, ECO:0000269\|PubMed:14718572}.
Top Pathways	Tight junction

CRB3 (C-15) - sc-27904 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CRB3 (K-20) - sc-27903 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CRB3 (K-20): sc-27903. Western blot analysis of CRB3 expression in non-transfected: sc-117750 (A) and human CRB3 transfected: sc-113019 (B) whole cell lysates.

CRB3 (N-20) - sc-27901 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CRB3 (H-88) - sc-292449 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-CRB3 antibody - ab173169 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CRB3 antibody (ab173169) at 1/100 dilution + mouse spleen tissue lysate at 35 µg

Anti-CRB3 antibody - ab67618 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-CRB3 antibody (ab67618) at 1/500 dilutionLane 1 : CRB3 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-CRB3 antibody - ab128362 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CRB3 antibody (ab128362) at 1 µg/ml + HepG2 cell lysate at 10 µg

Anti-CRB3 antibody [14F9] - ab180835 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rat
Clonality	Monoclonal
Clone	14F9

Immunofluorescence analysis of HeLa cell labeling CRB3 with ab1808350 at a 1/100 dilution. DAPI was used to stain the nuclei.

Anti-CRB3 Antibody (aa66-95, APC) - LS-C234210 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CRB3 Antibody (aa66-95, AP) - LS-C234209 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CRB3 Antibody (aa66-95, FITC) - LS-C234213 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CRB3 Antibody (aa66-95, Azide-free, HRP) - LS-C249750 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CRB3 Antibody (aa66-95, Biotin) - LS-C234212 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CRB3 Antibody - LS-C307079 from LifeSpan Bioscience

Host	Mouse
Clonality	Polyclonal

Anti-CRB3 Antibody (aa66-95, PE) - LS-C234214 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CRB3 Antibody (N-Terminus) - LS-C151132 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CRB3 Antibody (aa66-95) - LS-C320581 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CRB3 Antibody (aa66-95) - LS-C159403 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

CRB3 Antibody western blot of mouse spleen tissue lysates (35 ug/lane). The CRB3 antibody detected the CRB3 protein (arrow).

CRB3 Antibody - H00092359-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: CRB3 Antibody [H00092359-B01P] - Analysis of CRB3 expression in transfected 293T cell line by CRB3 polyclonal antibody. Lane 1: CRB3 transfected lysate(13.2 KDa). Lane 2: Non-transfected lysate.

CRB3 Antibody - NBP1-81185 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence: CRB3 Antibody [NBP1-81185] - Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.

CRB3 Antibody - NBP1-98328 from Novus Biologicals

Prices	$139.00, $329.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: CRB3 Antibody [NBP1-98328] - Titration: 1.0 ug/ml Positive Control: HepG2 Whole Cell.

Anti-CRB3 antibody produced in mouse - SAB1408190 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-CRB3: <B>Cat. No. SAB1408190</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~13.2 kDa using CRB3 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-CRB3 antibody produced in rabbit - HPA013835 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-CRB3: <B>Cat. No. HPA013835</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney shows strong membranous positivity in cells of glomeruli.

CRB3 antibody - N-terminal region (ARP42931_P050) - ARP42931_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CRB3-Antibody-Center - AP17560c from Abgent, a WuXi AppTec company

Prices	$99.00, $295.00
Sizes	80 µl, 400 µl
Host	Rabbit
Clonality	Polyclonal

CRB3 Antibody (Center) (Cat. #AP17560c) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the CRB3 antibody detected the CRB3 protein (arrow).

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