Gene Symbol | AHR |
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Entrez Gene | 196 |
Alt Symbol | bHLHe76 |
Species | Human |
Gene Type | protein-coding |
Description | aryl hydrocarbon receptor |
Other Description | AH-receptor|ah receptor|aromatic hydrocarbon receptor|class E basic helix-loop-helix protein 76 |
Swissprots | Q13803 Q13728 A4D130 Q13804 P35869 |
Accessions | AAA92082 AAA92083 AAA92084 BAA07235 CCO13674 EAL24281 EAW93686 EAW93687 P35869 AA329775 AK130815 AK307495 BC021696 BC069390 AAH69390 BC070080 AAH70080 BQ020427 BQ024331 BX505160 D16354 BAA03857 L19872 AAA16210 NM_001621 NP_001612 |
Function | Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. {ECO:0000269|PubMed:10395741, ECO:0000269|PubMed:7961644}. |
Subcellular Location | Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. |
Tissue Specificity | Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. {ECO:0000269|PubMed:7515333, ECO:0000269|PubMed:8246913}. |
Human Aryl hydrocarbon Receptor full length protein - ab152176 from Abcam
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Human Aryl hydrocarbon Receptor protein fragment - ab112247 from Abcam
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AHR Antibody Blocking Peptide - LS-E28737 from LifeSpan Bioscience
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AHR Antibody Blocking Peptide - LS-E28669 from LifeSpan Bioscience
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AHR Antibody Blocking Peptide - LS-E28670 from LifeSpan Bioscience
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AHR Antibody Blocking Peptide - LS-E28671 from LifeSpan Bioscience
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AHR Antibody Blocking Peptide - LS-E7876 from LifeSpan Bioscience
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AHR Antibody Blocking Peptide - LS-E11267 from LifeSpan Bioscience
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AHR Antibody Blocking Peptide - LS-E11055 from LifeSpan Bioscience
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Recombinant Human AHR Protein - H00000196-P01 from Novus Biologicals
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Recombinant Human AHR Protein - H00000196-Q01 from Novus Biologicals
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AHR-Antibody-Center-Blocking-peptide - BP5533c from Abgent, a WuXi AppTec company
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Human AhR Protein - abx065464 from Abbexa
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Ah receptor (AhR) - H00000196-P01 from Acris Antibodies
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Ah receptor (AhR) - H00000196-Q01-10 from Acris Antibodies
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Ah receptor (AhR) - H00000196-Q01-25 from Acris Antibodies
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Aryl Hydrocarbon Receptor (AhR), Human - 20-7665 from ARP American Research Products
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AHR fusion protein - Ag12240 from Proteintech Group
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AHR fusion protein - ag12193 from Proteintech Group
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Recombinant Human AHR, His-tagged - AHR-9497H from Creative Biomart
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Recombinant Human AhR, His-tagged - AhR-3644H from Creative Biomart
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Recombinant Human Aryl hydrocarbon receptor LBD/Hsp90 complex, GST-tagged - AHR-109H from Creative Biomart
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Recombinant Aryl Hydrocarbon Receptor (AhR) - RPB354Hu01 from Uscn Life Science Inc.
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Recombinant Aryl Hydrocarbon Receptor (AhR) - RPB354Mu01 from Uscn Life Science Inc.
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Recombinant Aryl Hydrocarbon Receptor (AhR) - RPB354Ra01 from Uscn Life Science Inc.
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