DACH2

Gene Symbol	DACH2
Entrez Gene	117154
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	dachshund family transcription factor 2
Other Description	dachshund homolog 2
Swissprots	Q8NAY3 Q8ND17 B4DQG3 B1AJV3 Q96N55 Q96NX9
Accessions	EAW98554 EAW98555 EAW98556 Q96NX9 AF428101 AAL26561 AK055953 BAB71054 AK091842 BAC03761 AK290596 BAF83285 AK294498 BAG57717 AK295648 BAG58518 AK298787 BAG60925 AL834456 CAD39116 BC040213 BC048423 BC114950 AAI14951 XM_011530846 XP_011529148 XM_011530847 XP_011529149 XM_011530848 XP_011529150 NM_001139514 NP_001132986 NM_001139515 NP_001132987 NM_053281 NP_444511
Function	Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain. {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000305}.

DACH2 (C-19) - sc-74392 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

DACH2 (P-17) - sc-74394 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-DACH2 antibody - N-terminal - ab171629 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-DACH2 antibody - N-terminal (ab171629) at 1/100 dilutionLane 1 : HepG2 cell line lysateLane 2 : Jurkat cell line lysateLysates/proteins at 35 µg per lane.SecondaryAnti-rabbit HRP conjugated antibody at 1/10000 dilutiondeveloped using the ECL technique

Anti-DACH2 Antibody (aa145-173, AP) - LS-C234401 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH2 Antibody (aa145-173, APC) - LS-C234403 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH2 Antibody (aa145-173, Biotin) - LS-C234404 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH2 Antibody (aa145-173, FITC) - LS-C234405 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH2 Antibody (aa145-173, PE) - LS-C234406 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH2 Antibody (aa144-173) - LS-C320729 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH2 Antibody (aa145-173, Azide-free, HRP) - LS-C249790 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH2 Antibody (aa525-574) - LS-C29920 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-DACH2 Antibody (aa169-181) - LS-C61729 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Antibody (0.03 ug/ml) staining of NIH3T3 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-DACH2 Antibody (C-Terminus) - LS-C201256 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Human MCF7. DACH2 antibody dilution 1.0 ug/ml.

Anti-DACH2 Antibody (aa145-173) - LS-C167261 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

DACH2 Antibody western blot of HepG2,Jurkat cell line lysates (35 ug/lane). The DACH2 antibody detected the DACH2 protein (arrow).

DACH2 Antibody - AF5230 from Novus Biologicals

Prices	$329.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

DACH2 Antibody - NBP1-89476 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: DACH2 Antibody [NBP1-89476] - Staining of human cerebellum shows distinct nuclear positivity in cerebellar tissue.

DACH2 Antibody - NBP1-80001 from Novus Biologicals

Prices	$139.00, $329.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: DACH2 Antibody [NBP1-80001] - Jurkat cell lysate, concentration 0.2-1 ug/ml.

DACH2 Antibody - NBP1-00177 from Novus Biologicals

Prices	$299.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Western Blot: DACH2 Antibody [NBP1-00177] - Analysis of DACH2 in NIH3T3 cell lysate (35ug protein in RIPA buffer) using NBP1-00177 at 0.3ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

DACH2 Polyclonal Antibody - bs-3659R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH2 antibody produced in rabbit - HPA000258 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-DACH2: <B>Cat. No. HPA000258</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human gall bladder tissue showing nuclear staining of glandular cells.

Anti-Dachshund Homolog 2/DACH2 antibody produced in goat - SAB2500290 from Sigma-Aldrich

Prices	$376.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-Dachshund homolog 2 / DACH2: <B>Cat. No. SAB2500290</B>: (0.03 μg/mL) staining of NIH3T3 cell lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-DACH2 antibody produced in rabbit - AV32425 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Tissue: liver (<B>Cat. No. AV32425</B>).<BR/><B>Specification</B><BR/>1. Antibody dilution (concentration) 4-8 μg/mL

DACH2 antibody - C-terminal region (ARP32425_P050) - ARP32425_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

DACH2 Antibody - C-terminal region (ARP32426_P050) - ARP32426_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

DACH2-Antibody-N-term - AP13241a from Abgent, a WuXi AppTec company

Prices	$99.00, $295.00
Sizes	80 µl, 400 µl
Host	Rabbit
Clonality	Polyclonal

DACH2 Antibody (N-term) (Cat. #AP13241a) western blot analysis in HepG2,Jurkat cell line lysates (35ug/lane).This demonstrates the DACH2 antibody detected the DACH2 protein (arrow).

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