DACH2
| Gene Symbol | DACH2 |
|---|---|
| Entrez Gene | 117154 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | dachshund family transcription factor 2 |
| Other Description | dachshund homolog 2 |
| Swissprots | Q8NAY3 Q8ND17 B4DQG3 B1AJV3 Q96N55 Q96NX9 |
| Accessions | EAW98554 EAW98555 EAW98556 Q96NX9 AF428101 AAL26561 AK055953 BAB71054 AK091842 BAC03761 AK290596 BAF83285 AK294498 BAG57717 AK295648 BAG58518 AK298787 BAG60925 AL834456 CAD39116 BC040213 BC048423 BC114950 AAI14951 XM_011530846 XP_011529148 XM_011530847 XP_011529149 XM_011530848 XP_011529150 NM_001139514 NP_001132986 NM_001139515 NP_001132987 NM_053281 NP_444511 |
| Function | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain. {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
DACH2 Overexpression Lysate (Native) - NBP2-05817 from Novus Biologicals
![Western Blot: DACH2 Overexpression Lysate (Adult Normal) [NBP2-05817] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DACH2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6302_DACH2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05817-img0001.jpg)
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Panoply™ Human DACH2 Knockdown Stable Cell Line - CSC-DC004009 from Creative biogene
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