| Gene Symbol |
KLHL41
|
| Entrez Gene |
10324
|
| Alt Symbol |
KBTBD10, Krp1, SARCOSIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kelch-like family member 41
|
| Other Description |
kel-like protein 23|kelch repeat and BTB (POZ) domain containing 10|kelch-like protein 41|kelch-related protein 1|sarcomeric muscle protein
|
| Swissprots |
Q53R42 O60662
|
| Accessions |
AAY24117 EAX11275 O60662 AA194290 AF056929 AAC13686 AF333387 AAG52886 AK316571 BAG38160 AY364252 AAQ76811 BC006534 AAH06534 DQ896002 ABM86980 EU176397 ABW03848 NM_006063 NP_006054
|
| Function |
Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. {ECO:0000250|UniProtKB:A2AUC9}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19424503}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A2AUC9}. Cell projection, pseudopodium {ECO:0000250|UniProtKB:Q9ER30}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9ER30}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:A2AUC9}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:24268659}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24268659}. Note=Predominantly cytoplasmic but can colocalize with F-actin at the membrane ruffle-like structures at the tips of transformation- specific pseudopodia. {ECO:0000269|PubMed:19424503}.
|
| Tissue Specificity |
Sarcomeric muscle.
|