Gene Symbol | KLHL41 |
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Entrez Gene | 10324 |
Alt Symbol | KBTBD10, Krp1, SARCOSIN |
Species | Human |
Gene Type | protein-coding |
Description | kelch-like family member 41 |
Other Description | kel-like protein 23|kelch repeat and BTB (POZ) domain containing 10|kelch-like protein 41|kelch-related protein 1|sarcomeric muscle protein |
Swissprots | Q53R42 O60662 |
Accessions | AAY24117 EAX11275 O60662 AA194290 AF056929 AAC13686 AF333387 AAG52886 AK316571 BAG38160 AY364252 AAQ76811 BC006534 AAH06534 DQ896002 ABM86980 EU176397 ABW03848 NM_006063 NP_006054 |
Function | Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. {ECO:0000250|UniProtKB:A2AUC9}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19424503}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A2AUC9}. Cell projection, pseudopodium {ECO:0000250|UniProtKB:Q9ER30}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9ER30}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:A2AUC9}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:24268659}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24268659}. Note=Predominantly cytoplasmic but can colocalize with F-actin at the membrane ruffle-like structures at the tips of transformation- specific pseudopodia. {ECO:0000269|PubMed:19424503}. |
Tissue Specificity | Sarcomeric muscle. |
KBTBD10 CRISPR/Cas9 KO Plasmid (h) - sc-408181 from Santa Cruz Biotechnology
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KBTBD10 HDR Plasmid (h) - sc-408181-HDR from Santa Cruz Biotechnology
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KBTBD10 Double Nickase Plasmid (h) - sc-408181-NIC from Santa Cruz Biotechnology
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KBTBD10 Double Nickase Plasmid (h2) - sc-408181-NIC-2 from Santa Cruz Biotechnology
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KBTBD10 CRISPR Activation Plasmid (h) - sc-408181-ACT from Santa Cruz Biotechnology
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KBTBD10 CRISPR Activation Plasmid (h2) - sc-408181-ACT-2 from Santa Cruz Biotechnology
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KBTBD10 Lentiviral Activation Particles (h) - sc-408181-LAC from Santa Cruz Biotechnology
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KBTBD10 Lentiviral Activation Particles (h2) - sc-408181-LAC-2 from Santa Cruz Biotechnology
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KBTBD10 siRNA (h) - sc-94395 from Santa Cruz Biotechnology
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KBTBD10 shRNA Plasmid (h) - sc-94395-SH from Santa Cruz Biotechnology
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KBTBD10 shRNA (h) Lentiviral Particles - sc-94395-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU001491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10904 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10904 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04776 from Sigma-Aldrich
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KLHL41 siRNA (Human) - CRH6996 from Cohesion Biosciences
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shRNA set against Human KBTBD10(NM_006063.2) - SHL187704 from Creative biogene
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Human KLHL41 siRNA - orb267498 from Biorbyt
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KLHL41 shRNA Plasmid (Human) - CHH6996 from Cohesion Biosciences
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KBTBD10 miRNA 3'UTR clone - MiUTR1H-05087 from Creative biogene
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