| Gene Symbol | PRSS22 |
|---|---|
| Entrez Gene | 64063 |
| Alt Symbol | BSSP-4, SP001LA, hBSSP-4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protease, serine, 22 |
| Other Description | brain-specific serine protease 4|prosemin|protease, serine S1 family member 22|serine protease 22|serine protease 26|tryptase epsilon |
| Swissprots | Q9GZN4 Q6UXE0 O43342 |
| Accessions | AAB93671 EAW85456 Q9GZN4 AB010779 BAB20263 AF321182 AAG35070 AK309624 AK310904 AW083723 AY358396 AAQ88762 BC009726 AAH09726 BQ893064 HQ447842 ADQ32326 XM_005255473 XP_005255530 XM_006720915 XP_006720978 NM_022119 NP_071402 |
| Function | Preferentially cleaves the synthetic substrate H-D-Leu- Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. {ECO:0000269|PubMed:11602603}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:11602603}. |
| Tissue Specificity | Expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and fetal lung. Scarce in adult lung. Expressed at low levels in placenta, pancreas, prostate and thyroid gland. {ECO:0000269|PubMed:11602603}. |
Tryptase ε siRNA (h) - sc-93094 from Santa Cruz Biotechnology
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Tryptase ε shRNA Plasmid (h) - sc-93094-SH from Santa Cruz Biotechnology
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Tryptase ε shRNA (h) Lentiviral Particles - sc-93094-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU160771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17533 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17533 from Sigma-Aldrich
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PRSS22 siRNA (Human) - CRJ1896 from Cohesion Biosciences
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shRNA set against Human PRSS22 (NM_022119.3) - SHH384388 from Creative biogene
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shRNA set against Human PRSS22(NM_022119.3) - SHR144072 from Creative biogene
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PRSS22 shRNA Plasmid (Human) - CHJ1896 from Cohesion Biosciences
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PRSS22 miRNA 3'UTR clone - MiUTR4H-TG07108 from Creative biogene
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