| Gene Symbol |
AGTRAP
|
| Entrez Gene |
57085
|
| Alt Symbol |
ATRAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
angiotensin II receptor-associated protein
|
| Other Description |
AT1 receptor-associated protein|ATI receptor-associated protein|angiotensin II, type I receptor-associated protein|type-1 angiotensin II receptor-associated protein
|
| Swissprots |
Q5SNV5 A8MVQ5 Q9NRW9 Q5SNV4 Q6RW13 Q96PL4 Q96AC0
|
| Accessions |
AAR25556 EAW71702 EAW71703 EAW71704 EAW71705 Q6RW13 AF165187 AAF89547 AF312374 AAL26806 AI741916 AK290042 BAF82731 BC011946 BC017328 AAH17328 BE782705 BI117521 BQ672962 CA866314 CD674964 DQ892619 ABM83545 DQ895859 ABM86785 XM_011541799 XP_011540101 XM_011541800 XP_011540102 XM_011541801 XP_011540103 XM_011541802 XP_011540104 XM_011541803 XP_011540105 NM_001040194 NP_001035284 NM_001040195 NP_001035285 NM_001040196 NP_001035286 NM_001040197 NP_001035287 NM_020350 NP_065083
|
| Function |
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. {ECO:0000269|PubMed:12960423}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein {ECO:0000269|PubMed:12960423}. Golgi apparatus membrane {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein {ECO:0000269|PubMed:12960423}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein {ECO:0000269|PubMed:12960423}. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
|
| Tissue Specificity |
Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. {ECO:0000269|PubMed:11733189}.
|