Gene Symbol | CCL8 |
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Entrez Gene | 6355 |
Alt Symbol | HC14, MCP-2, MCP2, SCYA10, SCYA8 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) ligand 8 |
Other Description | C-C motif chemokine 8|monocyte chemoattractant protein 2|monocyte chemotactic protein 2|small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)|small-inducible cytokine A8 |
Swissprots | P78388 P80075 A0AV77 |
Accessions | CAA68168 EAW80207 EAW80208 P80075 BC126242 AAI26243 HQ258700 ADR83451 Y10802 CAA71760 Y16645 CAA76341 NM_005623 NP_005614 |
Function | Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. {ECO:0000269|PubMed:9558113}. |
Subcellular Location | Secreted. |
Tissue Specificity | Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate. |
Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
MCP2 Human ELISA Kit - ab100587 from Abcam
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Mouse CCL8 / MCP2 ELISA Kit (Sandwich ELISA) - LS-F2848 from LifeSpan Bioscience
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Human CCL8 / MCP2 ELISA Kit (Sandwich ELISA) - LS-F2497 from LifeSpan Bioscience
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Pig CCL8 / MCP2 ELISA Kit (Sandwich ELISA) - LS-F6150 from LifeSpan Bioscience
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Bovine CCL8 / MCP2 ELISA Kit (Sandwich ELISA) - LS-F6149 from LifeSpan Bioscience
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Human CCL8 / MCP2 ELISA Kit (Sandwich ELISA) - LS-F147 from LifeSpan Bioscience
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Dog CCL8 / MCP2 ELISA Kit (Sandwich ELISA) - LS-F9855 from LifeSpan Bioscience
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Mouse CCL8 / MCP2 ELISA Kit (Sandwich ELISA) - LS-F11066 from LifeSpan Bioscience
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Human MCP-2 / CCL8 ELISA Kit - RAB0079 from Sigma-Aldrich
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CCL8/MCP-2 BioAssay ELISA Kit, Human - 143756 from USBiological Life Science
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Mouse CCL8/MCP-2 DuoSet ELISA - DY790 from R&D Systems
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Human CCL8/MCP-2 DuoSet ELISA - DY281 from R&D Systems
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Human MCP2 ELISA kit - 55R-1978 from Fitzgerald
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Murine MCP2 ELISA kit - 55R-27773 from Fitzgerald
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Human MCP-2 ELISA kit - abx050148 from Abbexa
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Human MCP2 ELISA Kit - abx056262 from Abbexa
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C-C motif chemokine 8, CCL8, Human, ELISA Kit - E0088h from ARP American Research Products
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CCL8/MCP-2, Human, ELISA Kit - PB-0442 from ARP American Research Products
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MCP-2, Human, ELISA Kit - BEK1144 from ARP American Research Products
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Monocyte Chemotactic Protein 2, MCP-2/CCL8, Human, ELISA Kit - E-EL-H1158 from ARP American Research Products
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Monocyte chemotactic protein 2, MCP-2, Human, ELISA Kit - CSB-E04656h from ARP American Research Products
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Monocyte Chemotactic Protein 2, MCP-2, Mouse, ELISA Kit - E-EL-M0794 from ARP American Research Products
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Monocyte Chemotactic Protein 2, MCP-2, Rat, ELISA Kit - E-EL-R0634 from ARP American Research Products
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Monocyte Chemotactic Protein 2, MCP-2/CCL8, Rabbit, ELISA Kit - E-EL-RB1777 from ARP American Research Products
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Monocyte Chemotactic Protein 2, MCP-2/CCL8, Chicken, ELISA Kit - E-EL-Ch0576 from ARP American Research Products
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