| Gene Symbol | CCL8 |
|---|---|
| Entrez Gene | 6355 |
| Alt Symbol | HC14, MCP-2, MCP2, SCYA10, SCYA8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 8 |
| Other Description | C-C motif chemokine 8|monocyte chemoattractant protein 2|monocyte chemotactic protein 2|small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)|small-inducible cytokine A8 |
| Swissprots | P78388 P80075 A0AV77 |
| Accessions | CAA68168 EAW80207 EAW80208 P80075 BC126242 AAI26243 HQ258700 ADR83451 Y10802 CAA71760 Y16645 CAA76341 NM_005623 NP_005614 |
| Function | Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. {ECO:0000269|PubMed:9558113}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |