| Gene Symbol |
ESYT2
|
| Entrez Gene |
57488
|
| Alt Symbol |
CHR2SYT, E-Syt2, FAM62B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
extended synaptotagmin-like protein 2
|
| Other Description |
chr2 synaptotagmin|extended synaptotagmin-2|family with sequence similarity 62 (C2 domain containing), member B
|
| Swissprots |
Q9BQS0 Q6UKI4 A4D229 Q9ULJ2 A0FGR8 Q6ZTU0 Q6ZVU1 Q9NW47 Q69YJ2
|
| Accessions |
A0FGR8 EAL23931 EAX04590 EAX04591 AB033054 BAA86542 AJ303365 CAC33887 AK001181 BAA91539 AK026710 AK056953 AK124091 BAC85769 AK126214 BAC86489 AK308824 AL833233 CAH10642 AY368150 AAR89381 BC013957 AAH13957 BC152806 AAI52807 DQ993201 ABJ97706 NM_020728 NP_065779
|
| Function |
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877}.
|
| Subcellular Location |
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Detected at sites of contact between the endoplasmic reticulum membrane and the cell membrane. Recruited to the cell membrane via the third C2 domain.
|
| Tissue Specificity |
Widely expressed with high level in cerebellum. {ECO:0000269|PubMed:17360437}.
|