ESYT2

Gene Symbol	ESYT2
Entrez Gene	57488
Alt Symbol	CHR2SYT, E-Syt2, FAM62B
Species	Human
Gene Type	protein-coding
Description	extended synaptotagmin-like protein 2
Other Description	chr2 synaptotagmin|extended synaptotagmin-2|family with sequence similarity 62 (C2 domain containing), member B
Swissprots	Q9BQS0 Q6UKI4 A4D229 Q9ULJ2 A0FGR8 Q6ZTU0 Q6ZVU1 Q9NW47 Q69YJ2
Accessions	A0FGR8 EAL23931 EAX04590 EAX04591 AB033054 BAA86542 AJ303365 CAC33887 AK001181 BAA91539 AK026710 AK056953 AK124091 BAC85769 AK126214 BAC86489 AK308824 AL833233 CAH10642 AY368150 AAR89381 BC013957 AAH13957 BC152806 AAI52807 DQ993201 ABJ97706 NM_020728 NP_065779
Function	Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877}.
Subcellular Location	Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Detected at sites of contact between the endoplasmic reticulum membrane and the cell membrane. Recruited to the cell membrane via the third C2 domain.
Tissue Specificity	Widely expressed with high level in cerebellum. {ECO:0000269|PubMed:17360437}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FAM62B full length protein - ab163566 from Abcam Category Protein Source Wheat germ Species Human

ESYT2 / E-Syt2 Antibody Blocking Peptide - LS-E17888 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FAM62B Protein - H00057488-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FAM62B Blocking Peptide - 33R-6875 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Extended synaptotagmin-2 - H00057488-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Extended synaptotagmin-2 - H00057488-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FAM62B fusion protein - ag20420 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

FAM62B fusion protein - ag20440 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Extended synaptotagmin-2 - TP324839 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

FAM62B Recombinant Protein Antigen - NBP1-85627PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ESYT2 Peptide, Human - M34GP05091H from Creative Peptides Category Peptide Source Synthetic. Species Human

Extended synaptotagmin-2 (ESYT2), Recombinant Protein - MBS963087 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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