PRKCA

Gene Symbol	PRKCA
Entrez Gene	5578
Alt Symbol	AAG6, PKC-alpha, PKCA, PRKACA
Species	Human
Gene Type	protein-coding
Description	protein kinase C, alpha
Other Description	PKC-A|aging-associated gene 6|protein kinase C alpha type
Swissprots	Q96RE4 P17252 B5BU22 Q15137 Q32M72
Accessions	AAK84184 ABY87554 AGC09604 CAJ00128 CAV30668 EAW89014 P17252 AA017296 AB209475 BAD92712 AB451258 BAG70072 AB451383 BAG70197 AF035594 AF035595 AF086287 AK055431 AK125425 AK130736 AL596674 AY633609 AAV33302 BC015855 BC053321 AAH53321 BC062759 BC071767 BC103691 BC107592 BC109273 AAI09274 BC109274 AAI09275 BC122530 BM015483 BQ018414 BU150006 BX648954 CA417000 EU832768 ACE87779 GQ129311 ACT64445 M22199 AAA60098 X52479 CAA36718 XM_011524989 XP_011523291 XM_011524990 XP_011523292 XM_011524991 XP_011523293 XM_011524992 XP_011523294 NM_002737 NP_002728
Function	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppr
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Nucleus.
Top Pathways	Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® PKCα Kinase Assay Kit - 7579 from Cell Signaling Technology Category Assay Kit

Mouse PRKCA / PKC-Alpha ELISA Kit (Sandwich ELISA) - LS-F6783 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.31 ng/ml Range 0.625-40 ng/ml

Rat PRKCA / PKC-Alpha ELISA Kit (Sandwich ELISA) - LS-F5724 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.237 ng/ml Range 0.625-40 ng/ml

Mouse/Human/Rat Phospho-PRKCA / PKC-Alpha (Tyr657) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1301 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.625-40 ng/ml

Mouse/Human/Rat Phospho-PRKCA / PKC-Alpha (Thr638) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1273 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.625-40 ng/ml

Mouse/Human/Rat PRKCA / PKC-Alpha ELISA Kit (Cell-Based ELISA) - LS-F2248 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.625-40 ng/ml

Human PRKCA / PKC-Alpha ELISA Kit (Sandwich ELISA) - LS-F9429 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 13.2 pg/ml Range 0.625-40 ng/ml

Human PRKCA / PKC-Alpha ELISA Kit (Sandwich ELISA) - LS-F11900 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.625-40 ng/ml

Human PKCa ELISA Kit - abx152752 from Abbexa Category ELISA Kit Sensitivity 0.054 ng/ml Range 0.156 ng/ml - 10 ng/ml

CAMP-dependent protein kinase catalytic subunit alpha (PRKACA), Human, ELISA Kit - E01C2401 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

cAMP-dependent protein kinase catalytic subunit alpha, PRKACA, Human, ELISA Kit - E1918h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.78-50 ng/mL

Protein Kinase C Alpha (PKCa), Human, ELISA Kit - SEB918Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.054ng/mL Range 0.156-10ng/mL

Protein kinase C alpha type, PRKCA, Human, ELISA Kit - E1380h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Protein kinase C, PKC, Human, ELISA Kit - CSB-E09389h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Human PKCa ELISA Kit - HP0677 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PKCa ELISA Kit - AP0677 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Protein Kinase C Alpha, ELISA Kit - MBS046849 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Alpha, ELISA Kit - MBS015112 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Alpha, ELISA Kit - MBS011033 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Alpha, ELISA Kit - MBS015906 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein kinase C alpha, ELISA Kit - MBS735527 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Alpha, ELISA Kit - MBS010539 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein kinase C Alpha, ELISA Kit - MBS729647 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Protein Kinase C Alpha, ELISA Kit - MBS016947 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Alpha, ELISA Kit - MBS014650 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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