PRKCA

Gene Symbol	PRKCA
Entrez Gene	5578
Alt Symbol	AAG6, PKC-alpha, PKCA, PRKACA
Species	Human
Gene Type	protein-coding
Description	protein kinase C, alpha
Other Description	PKC-A|aging-associated gene 6|protein kinase C alpha type
Swissprots	Q96RE4 P17252 B5BU22 Q15137 Q32M72
Accessions	AAK84184 ABY87554 AGC09604 CAJ00128 CAV30668 EAW89014 P17252 AA017296 AB209475 BAD92712 AB451258 BAG70072 AB451383 BAG70197 AF035594 AF035595 AF086287 AK055431 AK125425 AK130736 AL596674 AY633609 AAV33302 BC015855 BC053321 AAH53321 BC062759 BC071767 BC103691 BC107592 BC109273 AAI09274 BC109274 AAI09275 BC122530 BM015483 BQ018414 BU150006 BX648954 CA417000 EU832768 ACE87779 GQ129311 ACT64445 M22199 AAA60098 X52479 CAA36718 XM_011524989 XP_011523291 XM_011524990 XP_011523292 XM_011524991 XP_011523293 XM_011524992 XP_011523294 NM_002737 NP_002728
Function	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppr
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Nucleus.
Top Pathways	Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® PKCα siRNA I - 13292 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

PKC α CRISPR/Cas9 KO Plasmid (h) - sc-400128 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC α HDR Plasmid (h) - sc-400128-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC α Double Nickase Plasmid (h) - sc-400128-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC α Double Nickase Plasmid (h2) - sc-400128-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC α CRISPR Activation Plasmid (h) - sc-400128-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC α CRISPR Activation Plasmid (h2) - sc-400128-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC α Lentiviral Activation Particles (h) - sc-400128-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC α Lentiviral Activation Particles (h2) - sc-400128-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC siRNA (h) - sc-29449 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC shRNA Plasmid (h) - sc-29449-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC shRNA (h) Lentiviral Particles - sc-29449-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC α siRNA (h) - sc-36243 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC α shRNA Plasmid (h) - sc-36243-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC α shRNA (h) Lentiviral Particles - sc-36243-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC α siRNA (h2) - sc-44227 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC α shRNA Plasmid (h2) - sc-44227-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC α shRNA (h2) Lentiviral Particles - sc-44227-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC alpha RNAi - H00005578-R03 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU050821 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1819 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1820 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1818 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1055 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1055 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

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