PRKCA

Gene Symbol	PRKCA
Entrez Gene	5578
Alt Symbol	AAG6, PKC-alpha, PKCA, PRKACA
Species	Human
Gene Type	protein-coding
Description	protein kinase C, alpha
Other Description	PKC-A|aging-associated gene 6|protein kinase C alpha type
Swissprots	Q96RE4 P17252 B5BU22 Q15137 Q32M72
Accessions	AAK84184 ABY87554 AGC09604 CAJ00128 CAV30668 EAW89014 P17252 AA017296 AB209475 BAD92712 AB451258 BAG70072 AB451383 BAG70197 AF035594 AF035595 AF086287 AK055431 AK125425 AK130736 AL596674 AY633609 AAV33302 BC015855 BC053321 AAH53321 BC062759 BC071767 BC103691 BC107592 BC109273 AAI09274 BC109274 AAI09275 BC122530 BM015483 BQ018414 BU150006 BX648954 CA417000 EU832768 ACE87779 GQ129311 ACT64445 M22199 AAA60098 X52479 CAA36718 XM_011524989 XP_011523291 XM_011524990 XP_011523292 XM_011524991 XP_011523293 XM_011524992 XP_011523294 NM_002737 NP_002728
Function	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppr
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Nucleus.
Top Pathways	Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PKC alpha full length protein - ab55672 from Abcam Category Protein Prices $239.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Active X. laevis PKC alpha full length protein - ab60839 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Xenopus

Human PKC alpha (phospho S657 + Y658) peptide - ab42755 from Abcam Category Peptide Species Human

Human PKC alpha peptide - ab71206 from Abcam Category Peptide

Human PKC alpha protein fragment - ab159197 from Abcam Category Protein Source Wheat germ Species Human

PKC alpha peptide - ab133953 from Abcam Category Peptide

PKC alpha peptide - ab178734 from Abcam Category Peptide

PKC alpha peptide - ab178750 from Abcam Category Peptide

PRKACA Antibody Blocking Peptide - LS-E21139 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKACA Antibody Blocking Peptide - LS-E21140 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKACA Antibody Blocking Peptide - LS-E8483 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKACA Antibody Blocking Peptide - LS-E8604 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCA / PKC-Alpha Antibody Blocking Peptide - LS-E3137 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCA / PKC-Alpha Antibody Blocking Peptide - LS-E8605 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCA / PKC-Alpha Antibody Blocking Peptide - LS-E9651 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKC alpha Partial Recombinant Protein - H00005578-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PKA C alpha Partial Recombinant Protein - H00005566-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PKA C alpha Recombinant Protein - H00005566-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 10 ug 25 ug Species Human

Recombinant Human PKA C alpha Protein - H00005566-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PKC alpha Protein - P4198 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Source Insect Species Human

PKA C alpha Recombinant Protein - P4226 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

PKC alpha Recombinant Protein - P4753 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant PKA C alpha Protein - NBP1-99491 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Recombinant PKC alpha Protein - NBP1-99883 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

PKC alpha Peptide - P1574 from Novus Biologicals Category Peptide Species Human

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