RARRES2

Gene Symbol	RARRES2
Entrez Gene	5919
Alt Symbol	HP10433, TIG2
Species	Human
Gene Type	protein-coding
Description	retinoic acid receptor responder (tazarotene induced) 2
Other Description	RAR-responsive protein TIG2|chemerin|retinoic acid receptor responder protein 2|tazarotene-induced gene 2 protein
Swissprots	Q99969 Q7LE02
Accessions	AAS00384 EAL24473 EAW54120 EAW54121 Q99969 AB015632 BAA76499 AK092804 AK312197 BAG35130 BC000069 AAH00069 BM919890 BX448753 CR541992 CAG46789 CR542026 CAG46823 U77594 AAB47975 NM_002889 NP_002880
Function	Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic facto
Subcellular Location	Secreted {ECO:0000305}.
Tissue Specificity	Expressed at the highest levels in placenta, liver, and white adipose tissue (WAT), and to a lesser extent in many other tissues such as lung, brown adipose tissue, heart, ovary, kidney, skeletal muscle and pancreas. Within WAT, expression is enriched in adipocytes as compared to the stromal vascular fraction. Expression and secretion increases dramatically with adipogenesis. Highly expressed in skin (basal and suprabasal layers of the epidermis, hair follicles and endothelial cells). Expression is elevated in numerous metabolic and inflammatory diseases including psoriasis, obesity, type 2 diabetes, metabolic syndrome and cardiovascular disease. {ECO:0000269|PubMed:17635925, ECO:0000269|PubMed:17767914, ECO:0000269|PubMed:23527010}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Chemerin Human ELISA Kit - ab155430 from Abcam Category ELISA Kit Prices $499.00 Sizes 1 x 96 tests Sensitivity < 0.5 ng/ml Range 0.51 ng/ml - 50 ng/ml

Rat RARRES2 / Chemerin ELISA Kit (Sandwich ELISA) - LS-F6900 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 6.7 pg/ml Range 0.205-20 ng/ml

Mouse RARRES2 / Chemerin ELISA Kit (Sandwich ELISA) - LS-F2981 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 20 pg/ml Range 0.205-20 ng/ml

Human RARRES2 / Chemerin ELISA Kit (Sandwich ELISA) - LS-F2980 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 20 pg/ml Range 0.205-20 ng/ml

Human RARRES2 / Chemerin ELISA Kit (Sandwich ELISA) - LS-F4641 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.067 ng/ml Range 0.205-20 ng/ml

Human RARRES2 / Chemerin ELISA Kit (Sandwich ELISA) - LS-F55 from LifeSpan Bioscience Category ELISA Kit Prices $620.00, $1,090.00, $2,380.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 0.205 ng/ml Range 0.205-20 ng/ml

Mouse RARRES2 / Chemerin ELISA Kit (Custom ELISA) - LS-F376 from LifeSpan Bioscience Category ELISA Kit Prices $670.00, $1,190.00, $2,570.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity To be determined Range 0.205-20 ng/ml

Mouse RARRES2 / Chemerin ELISA Kit (Sandwich ELISA) - LS-F8744 from LifeSpan Bioscience Category ELISA Kit Prices $480.00 Sizes 1 plate Sensitivity 0.123 ng/ml Range 0.205-20 ng/ml

Mouse RARRES2 / Chemerin ELISA Kit (Sandwich ELISA) - LS-F10348 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 0.411 ng/ml Range 0.205-20 ng/ml

Human RARRES2 / Chemerin ELISA Kit (Sandwich ELISA) - LS-F12472 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.156 Range 0.205-20 ng/ml

Mouse RARRES2 / Chemerin ELISA Kit (Sandwich ELISA) - LS-F12473 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 31.2 Range 0.205-20 ng/ml

Human RARRES2 / Retinoic Acid Receptor Responder Protein 2 ELISA Kit - RAB0532 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt Sensitivity 0.5 ng/mL

Human Chemerin Quantikine ELISA - DCHM00 from R&D Systems Category ELISA Kit Prices $519.00 Sizes 1 kit Sensitivity 7.8 pg/mL Range 78.0 - 5,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

Human Chemerin DuoSet ELISA - DY2324 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Mouse Chemerin Quantikine ELISA Kit - MCHM00 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 3.47 pg/mL Range 46.9 - 3,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

Mouse Chemerin DuoSet ELISA - DY2325 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 15.60 - 1,000 pg/mL

Quantikine Immunoassay Control Set 780 for Human Chemerin - QC62 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human Chemerin ELISA Kit - abx151050 from Abbexa Category ELISA Kit Sensitivity 0.058 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human Chemerin ELISA Kit - abx051420 from Abbexa Category ELISA Kit Sensitivity 6 pg/ml Range 32 pg/ml - 2000 pg/ml

Chemerin (CHEM), Human, ELISA Kit - SEA945Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.058ng/mL Range 0.156-10ng/mL

Chemerin, Human, ELISA Kit - CSB-E10398h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Chemerin, Human, ELISA Kit - E01C0104 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0pg/ml Range 25-500pg/ml

Chemerin, Human, ELISA Kit - YHB0680Hu from ARP American Research Products Category ELISA Kit

Chemerin, CHEM, Human, ELISA Kit - E-EL-H0698 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Retinoic acid receptor responder protein 2, RARRES2, Human, ELISA Kit - E0945h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.156-10 ng/mL

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