RARRES2

Gene Symbol	RARRES2
Entrez Gene	5919
Alt Symbol	HP10433, TIG2
Species	Human
Gene Type	protein-coding
Description	retinoic acid receptor responder (tazarotene induced) 2
Other Description	RAR-responsive protein TIG2|chemerin|retinoic acid receptor responder protein 2|tazarotene-induced gene 2 protein
Swissprots	Q99969 Q7LE02
Accessions	AAS00384 EAL24473 EAW54120 EAW54121 Q99969 AB015632 BAA76499 AK092804 AK312197 BAG35130 BC000069 AAH00069 BM919890 BX448753 CR541992 CAG46789 CR542026 CAG46823 U77594 AAB47975 NM_002889 NP_002880
Function	Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic facto
Subcellular Location	Secreted {ECO:0000305}.
Tissue Specificity	Expressed at the highest levels in placenta, liver, and white adipose tissue (WAT), and to a lesser extent in many other tissues such as lung, brown adipose tissue, heart, ovary, kidney, skeletal muscle and pancreas. Within WAT, expression is enriched in adipocytes as compared to the stromal vascular fraction. Expression and secretion increases dramatically with adipogenesis. Highly expressed in skin (basal and suprabasal layers of the epidermis, hair follicles and endothelial cells). Expression is elevated in numerous metabolic and inflammatory diseases including psoriasis, obesity, type 2 diabetes, metabolic syndrome and cardiovascular disease. {ECO:0000269|PubMed:17635925, ECO:0000269|PubMed:17767914, ECO:0000269|PubMed:23527010}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Chemerin protein fragment - ab124314 from Abcam Category Protein Prices $239.00 Sizes 25 µg Source E. coli Species Human

Human Chemerin protein fragment - ab104356 from Abcam Category Protein Source E. coli Species Human

Human Chemerin protein fragment - ab157064 from Abcam Category Protein Source HEK 293 cells Species Human

Human Chemerin protein fragment - ab156357 from Abcam Category Protein Source E. coli Species Human

Chemerin Partial Recombinant Protein - H00005919-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Chemerin Partial Recombinant Protein - H00005919-Q01 from Novus Biologicals Category Protein Species Human

Chemerin Recombinant Protein - H00005919-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human Chemerin Protein - NBP2-23412 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Chemerin Recombinant Protein - P4378 from Novus Biologicals Category Protein Prices $549.00 Sizes 25 µg Species Human

Recombinant Human Chemerin Protein - NBP1-99310 from Novus Biologicals Category Protein Prices $185.00 Sizes 25 µg Source E. coli Species Human

Chemerin Protein - NBP1-99707 from Novus Biologicals Category Protein Species Human

TIG2 recombinant protein - GTX53824 from GeneTex Category Protein Prices $199.00 Sizes 25 μg Source E. Coli

Recombinant Human Chemerin - 2324-CM-025 from R&D Systems Category Protein Source E. coli-derived, Glu21-Ser157, with an N-terminal Met

Recombinant Human Chemerin, CF - 2324-CM-025/CF from R&D Systems Category Protein Source E. coli-derived, Glu21-Ser157, with an N-terminal Met

RARRES2 Protein (OPPA02165) - OPPA02165 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Recombinant Chemerin (OPSD00034) - OPSD00034 from Aviva Systems Biology Category Protein Prices $105.00 Sizes 5 µg

Human RARRES2 protein (His Tag) - orb191144 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

Human RARRES2 protein - orb81307 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

Human RARRES2 protein - orb246618 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Chemerin protein - 30R-2418 from Fitzgerald Category Protein Prices $275.00 Sizes 25 µg Source E.coli Species Human

RARRES2 protein (His tag) - 80R-2796 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Human Chemerin Protein - abx065859 from Abbexa Category Protein Source E.coli Species Human

Mouse Chemerin Protein - abx065861 from Abbexa Category Protein Source E.coli Species Mouse

TIG2 Blocking Peptide - abx063185 from Abbexa Category Peptide Species Human, Mouse, Rat

RARRES2 - AR20015PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 25 µg Source E. coli Species Human

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