RARRES2

Gene Symbol RARRES2
Entrez Gene 5919
Alt Symbol HP10433, TIG2
Species Human
Gene Type protein-coding
Description retinoic acid receptor responder (tazarotene induced) 2
Other Description RAR-responsive protein TIG2|chemerin|retinoic acid receptor responder protein 2|tazarotene-induced gene 2 protein
Swissprots Q99969 Q7LE02
Accessions AAS00384 EAL24473 EAW54120 EAW54121 Q99969 AB015632 BAA76499 AK092804 AK312197 BAG35130 BC000069 AAH00069 BM919890 BX448753 CR541992 CAG46789 CR542026 CAG46823 U77594 AAB47975 NM_002889 NP_002880
Function Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic facto
Subcellular Location Secreted {ECO:0000305}.
Tissue Specificity Expressed at the highest levels in placenta, liver, and white adipose tissue (WAT), and to a lesser extent in many other tissues such as lung, brown adipose tissue, heart, ovary, kidney, skeletal muscle and pancreas. Within WAT, expression is enriched in adipocytes as compared to the stromal vascular fraction. Expression and secretion increases dramatically with adipogenesis. Highly expressed in skin (basal and suprabasal layers of the epidermis, hair follicles and endothelial cells). Expression is elevated in numerous metabolic and inflammatory diseases including psoriasis, obesity, type 2 diabetes, metabolic syndrome and cardiovascular disease. {ECO:0000269|PubMed:17635925, ECO:0000269|PubMed:17767914, ECO:0000269|PubMed:23527010}.

TIG2 (E-7) - sc-373797 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIG2 (E-7): sc-373797. Western blot analysis of TIG2 expression in human lung (A), human heart (B) and human liver (C) tissue extracts.

TIG2 (H-143) - sc-135254 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TIG2 (H-143): sc-135254. Western blot analysis of TIG2 expression in human testis (A) and human lung (B) tissue extracts.

TIG2 (K-15) - sc-47482 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIG2 (K-15): sc-47482. Western blot analysis of TIG2 expression in human lung (A) and human heart (B) tissue extracts.

TIG2 (N-13) - sc-47483 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIG2 (N-13): sc-47483. Western blot analysis of TIG2 expression in human heart tissue extract.

TIG2 (C-12) - sc-47479 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIG2 (C-12): sc-47479. Western blot analysis of TIG2 expression in rat lung (A), rat heart (B) and rat liver (C) tissue extracts.

Anti-Chemerin antibody - ab72965 from Abcam

Prices $379.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Chemerin antibody (ab72965) at 1/500 dilutionLane 1 : Chemerin transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-Chemerin antibody - ab103153 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab103153 stained HeLa cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab103153 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Chemerin antibody - ab203040 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed and paraffin embedded rat brain tissue sections labeling Chemerin at 1/200, followed by conjugation to the secondary antibody and DAB staining.

Anti-Chemerin antibody - ab201292 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Chemerin antibody (ab201292)Lane 1 : A549 whole cell lysateLane 2 : Raw 264.7 whole cell lysateLane 3 : H9C2 whole cell lysate

Anti-Chemerin antibody [Tigy-1] - ab112520 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Tigy-1

Anti-Chemerin antibody [Tigy-2] - ab112540 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Tigy-2

Anti-RARRES2 / Chemerin Antibody - LS-C35907 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-RARRES2 / Chemerin Antibody (aa21-157, clone 365317) - LS-C35908 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 365317

Anti-RARRES2 / Chemerin Antibody (aa17-156) - LS-C128080 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Rat
Clonality Monoclonal

Anti-RARRES2 / Chemerin Antibody (aa17-156, Biotin) - LS-C128079 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-RARRES2 / Chemerin Antibody (aa72-93) - LS-C143787 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-RARRES2 / Chemerin Antibody (aa33-158, Biotin) - LS-C297464 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RARRES2 / Chemerin Antibody (aa33-158) - LS-C293291 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant RARRES2 / Chemerin.

Anti-RARRES2 / Chemerin Antibody (aa25-152, Biotin) - LS-C297465 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RARRES2 / Chemerin Antibody (aa33-158, Biotin) - LS-C299312 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RARRES2 / Chemerin Antibody (aa25-152) - LS-C293294 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant RARRES2 / Chemerin.

Anti-RARRES2 / Chemerin Antibody (aa33-158) - LS-C293292 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant RARRES2 / Chemerin.

Anti-RARRES2 / Chemerin Antibody (aa33-158, FITC) - LS-C301854 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RARRES2 / Chemerin Antibody (aa25-152, FITC) - LS-C301856 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RARRES2 / Chemerin Antibody (aa33-158, FITC) - LS-C304541 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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