ROCK2
| Gene Symbol | ROCK2 |
|---|---|
| Entrez Gene | 9475 |
| Alt Symbol | ROCK-II |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rho-associated, coiled-coil containing protein kinase 2 |
| Other Description | p164 ROCK-2|rho-associated protein kinase 2|rho-associated, coiled-coil-containing protein kinase II |
| Swissprots | Q9UQN5 Q53SJ7 Q53QZ0 O75116 |
| Accessions | AAX93049 AAY14825 EAX00937 EAX00938 O75116 AB014519 BAA31594 AK299296 BAG61311 AK310358 AL049383 BC111801 AAI11802 BG539531 CD652480 D87931 BAA75636 XM_005246190 XP_005246247 XM_011510417 XP_011508719 NM_004850 NP_004841 |
| Function | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca |
| Subcellular Location | Cytoplasm. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane. {ECO:0000250}. |
| Top Pathways | cGMP-PKG signaling pathway, Proteoglycans in cancer, cAMP signaling pathway, Sphingolipid signaling pathway, Wnt signaling pathway |
HTScan ® ROCK2 Kinase Assay Kit - 7508 from Cell Signaling Technology
|
||||||||||
Human ROCK2 ELISA Kit - LS-F5023 from LifeSpan Bioscience
|
||||||||||
Mouse/Human/Rat ROCK2 ELISA Kit (Sandwich ELISA) - LS-F9189 from LifeSpan Bioscience
|
||||||||||
Rabbit anti-ROCK2 Antibody, Affinity Purified - PLA0013 from Sigma-Aldrich
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2), Human, ELISA Kit - SEB852Hu from ARP American Research Products
|
||||||||||
Rho-associated protein kinase 2, ROCK2, Human, ELISA Kit - E1852h from ARP American Research Products
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, Rock-2, Human, ELISA Kit - E-EL-H0923 from ARP American Research Products
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, Rock-2, Rabbit, ELISA Kit - E-EL-RB1531 from ARP American Research Products
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, Rock-2, Chicken, ELISA Kit - E-EL-Ch1799 from ARP American Research Products
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, Rock-2, Porcine, ELISA Kit - E-EL-P1911 from ARP American Research Products
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, Rock-2, Monkey, ELISA Kit - E-EL-MK0028 from ARP American Research Products
|
||||||||||
Human Rock-2(Rho Associated Coiled Coil Containing Protein Kinase 2) ELISA Kit - E-EL-H0923 from Elabscience
|
||||||||||
Human Rock-2 (Rho Associated Coiled Coil Containing Protein Kinase 2) CLIA Kit - E-CL-H0629 from Elabscience
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS106505 from MyBioSource
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS089615 from MyBioSource
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS091686 from MyBioSource
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS070444 from MyBioSource
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS091192 from MyBioSource
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS071740 from MyBioSource
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS080986 from MyBioSource
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS086109 from MyBioSource
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS055137 from MyBioSource
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS051056 from MyBioSource
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS106885 from MyBioSource
|
||||||||||
Rho Associated Coiled Coil Containing Protein Kinase 2, ELISA Kit - MBS056720 from MyBioSource
|