ROCK2

Gene Symbol	ROCK2
Entrez Gene	9475
Alt Symbol	ROCK-II
Species	Human
Gene Type	protein-coding
Description	Rho-associated, coiled-coil containing protein kinase 2
Other Description	p164 ROCK-2|rho-associated protein kinase 2|rho-associated, coiled-coil-containing protein kinase II
Swissprots	Q9UQN5 Q53SJ7 Q53QZ0 O75116
Accessions	AAX93049 AAY14825 EAX00937 EAX00938 O75116 AB014519 BAA31594 AK299296 BAG61311 AK310358 AL049383 BC111801 AAI11802 BG539531 CD652480 D87931 BAA75636 XM_005246190 XP_005246247 XM_011510417 XP_011508719 NM_004850 NP_004841
Function	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca
Subcellular Location	Cytoplasm. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane. {ECO:0000250}.
Top Pathways	cGMP-PKG signaling pathway, Proteoglycans in cancer, cAMP signaling pathway, Sphingolipid signaling pathway, Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ROCK2 (D1B1) Rabbit mAb - 9029 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D1B1

ROCK2 Antibody - 8236 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Rock-2 (C-20) - sc-1851 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rock-2 (D-2) - sc-365275 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rock-2 (D-11) - sc-398519 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rock-2 (N-19) - sc-1852 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rock-2 (H-85) - sc-5561 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Rock-2 (30-J) - sc-100425 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-ROCK2 (phospho T249) antibody - ab83514 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROCK2 (phospho Y722) antibody - ab182648 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ROCK2 antibody - ab71598 from Abcam Prices $395.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROCK2 antibody - ab66320 from Abcam Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROCK2 antibody - ab56661 from Abcam Prices $387.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ROCK2 antibody - ab137697 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ROCK2 antibody - ab183636 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ROCK2 antibody - ab85612 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROCK2 antibody - ab110433 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROCK2 antibody [EPR7140(2)] - ab134904 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7140(2)

Anti-ROCK2 antibody [EPR7141(B)] - ab125025 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7141(B)

Anti-ROCK2 Antibody (aa2-543) - LS-C38946 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-ROCK2 Antibody - LS-C48711 from LifeSpan Bioscience Prices $410.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ROCK2 Antibody (aa1-100) - LS-C93368 from LifeSpan Bioscience Prices $575.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROCK2 Antibody (C-Terminus) - LS-C93369 from LifeSpan Bioscience Prices $545.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROCK2 Antibody (N-Terminus) - LS-C122396 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROCK2 Antibody IHC-plus™ - LS-B3050 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

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