| Gene Symbol |
ROCK2
|
| Entrez Gene |
9475
|
| Alt Symbol |
ROCK-II
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho-associated, coiled-coil containing protein kinase 2
|
| Other Description |
p164 ROCK-2|rho-associated protein kinase 2|rho-associated, coiled-coil-containing protein kinase II
|
| Swissprots |
Q9UQN5 Q53SJ7 Q53QZ0 O75116
|
| Accessions |
AAX93049 AAY14825 EAX00937 EAX00938 O75116 AB014519 BAA31594 AK299296 BAG61311 AK310358 AL049383 BC111801 AAI11802 BG539531 CD652480 D87931 BAA75636 XM_005246190 XP_005246247 XM_011510417 XP_011508719 NM_004850 NP_004841
|
| Function |
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca
|
| Subcellular Location |
Cytoplasm. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane. {ECO:0000250}.
|
| Top Pathways |
cGMP-PKG signaling pathway, Proteoglycans in cancer, cAMP signaling pathway, Sphingolipid signaling pathway, Wnt signaling pathway
|
