ROCK2

Gene Symbol	ROCK2
Entrez Gene	9475
Alt Symbol	ROCK-II
Species	Human
Gene Type	protein-coding
Description	Rho-associated, coiled-coil containing protein kinase 2
Other Description	p164 ROCK-2|rho-associated protein kinase 2|rho-associated, coiled-coil-containing protein kinase II
Swissprots	Q9UQN5 Q53SJ7 Q53QZ0 O75116
Accessions	AAX93049 AAY14825 EAX00937 EAX00938 O75116 AB014519 BAA31594 AK299296 BAG61311 AK310358 AL049383 BC111801 AAI11802 BG539531 CD652480 D87931 BAA75636 XM_005246190 XP_005246247 XM_011510417 XP_011508719 NM_004850 NP_004841
Function	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca
Subcellular Location	Cytoplasm. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane. {ECO:0000250}.
Top Pathways	cGMP-PKG signaling pathway, Proteoglycans in cancer, cAMP signaling pathway, Sphingolipid signaling pathway, Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ROCK2 protein fragment - ab125828 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human ROCK2 protein fragment - ab51423 from Abcam Category Protein Prices $302.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human ROCK2 peptide - ab71596 from Abcam Category Peptide

Human ROCK2 peptide - ab71597 from Abcam Category Peptide

Human ROCK2 protein fragment - ab160505 from Abcam Category Protein Source Wheat germ Species Human

ROCK2 peptide - ab111859 from Abcam Category Peptide

ROCK2 Antibody Blocking Peptide - LS-E25171 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ROCK2 Antibody Blocking Peptide - LS-E31112 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ROCK2 Partial Recombinant Protein - H00009475-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ROCK2 Protein - P3914 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Source Insect Species Human

ROCK2 Recombinant Protein - P4770 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

ROCK2 Blocking Peptide - NBP1-76570PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

ROCK2 Blocking Peptide - 33R-10352 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ROCK2 Blocking Peptide - abx063590 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig, Sheep

ROCK2 - H00009475-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ROCK2 - H00009475-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ROCK2 - P3914 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

ROCK2 - P4770 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

ROCK2 control peptide - AP26129CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

ROCK2 Peptide - 6297P from ProSci Category Peptide Species Human

ROCK2 fusion protein - ag16800 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ROCK2 fusion protein - Ag16330 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human ROCK2, GST-tagged, Active - ROCK2-421H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human ROCK2, GST-His - ROCK2-712H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human ROCK2 - ROCK2-30955TH from Creative Biomart Category Protein

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