| Gene Symbol |
UBE2Z
|
| Entrez Gene |
65264
|
| Alt Symbol |
HOYS7, USE1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2Z
|
| Other Description |
UBA6-specific enzyme E2|uba6-specific E2 conjugating enzyme 1|ubiquitin carrier protein Z|ubiquitin-conjugating enzyme E2 Z|ubiquitin-protein ligase Z
|
| Swissprots |
A6NC60 Q9H832 Q8TCM4 Q7L354 Q9H893 A6N8M6
|
| Accessions |
EAW94701 EAW94702 EAW94703 EAW94704 Q9H832 AA843379 AA845421 AB025426 BAB87810 AK023917 BAB14724 AK024030 BAB14789 AK091644 AK122770 AK130303 AK296865 BAG59428 AL713782 CAD28542 BC015169 AAH15169 BC015890 AAH15890 CR457322 CAG33603 DA928380 EF623992 ABR25252 NM_023079 NP_075567
|
| Function |
Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. {ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000269|PubMed:17464193, ECO:0000269|PubMed:17597759}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17160626}. Nucleus {ECO:0000269|PubMed:17160626}.
|
| Tissue Specificity |
Widely expressed. Highly in placenta, pancreas, spleen and testis. {ECO:0000269|PubMed:17160626, ECO:0000269|PubMed:17597759}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|
![Western Blot: UBE2Z Overexpression Lysate (Adult Normal) [NBP2-06389] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UBE2Z.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/17152_UBE2Z%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-06389-img0001.jpg)