Gene Symbol | UBE2Z |
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Entrez Gene | 65264 |
Alt Symbol | HOYS7, USE1 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin-conjugating enzyme E2Z |
Other Description | UBA6-specific enzyme E2|uba6-specific E2 conjugating enzyme 1|ubiquitin carrier protein Z|ubiquitin-conjugating enzyme E2 Z|ubiquitin-protein ligase Z |
Swissprots | A6NC60 Q9H832 Q8TCM4 Q7L354 Q9H893 A6N8M6 |
Accessions | EAW94701 EAW94702 EAW94703 EAW94704 Q9H832 AA843379 AA845421 AB025426 BAB87810 AK023917 BAB14724 AK024030 BAB14789 AK091644 AK122770 AK130303 AK296865 BAG59428 AL713782 CAD28542 BC015169 AAH15169 BC015890 AAH15890 CR457322 CAG33603 DA928380 EF623992 ABR25252 NM_023079 NP_075567 |
Function | Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. {ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000269|PubMed:17464193, ECO:0000269|PubMed:17597759}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17160626}. Nucleus {ECO:0000269|PubMed:17160626}. |
Tissue Specificity | Widely expressed. Highly in placenta, pancreas, spleen and testis. {ECO:0000269|PubMed:17160626, ECO:0000269|PubMed:17597759}. |
Top Pathways | Ubiquitin mediated proteolysis |
UBE2Z CRISPR/Cas9 KO Plasmid (h) - sc-413085 from Santa Cruz Biotechnology
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UBE2Z HDR Plasmid (h) - sc-413085-HDR from Santa Cruz Biotechnology
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UBE2Z Double Nickase Plasmid (h) - sc-413085-NIC from Santa Cruz Biotechnology
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UBE2Z Double Nickase Plasmid (h2) - sc-413085-NIC-2 from Santa Cruz Biotechnology
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UBE2Z CRISPR Activation Plasmid (h) - sc-413085-ACT from Santa Cruz Biotechnology
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UBE2Z CRISPR Activation Plasmid (h2) - sc-413085-ACT-2 from Santa Cruz Biotechnology
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UBE2Z Lentiviral Activation Particles (h) - sc-413085-LAC from Santa Cruz Biotechnology
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UBE2Z Lentiviral Activation Particles (h2) - sc-413085-LAC-2 from Santa Cruz Biotechnology
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UBE2Z siRNA (h) - sc-93728 from Santa Cruz Biotechnology
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UBE2Z shRNA Plasmid (h) - sc-93728-SH from Santa Cruz Biotechnology
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UBE2Z shRNA (h) Lentiviral Particles - sc-93728-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU063691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22391 from Sigma-Aldrich
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UBE2Z siRNA (Human) - CRJ2200 from Cohesion Biosciences
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UBE2Z RNAi - H00065264-R01 from Novus Biologicals
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UBE2Z - MBS828397 from MyBioSource
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shRNA set against Human UBE2Z (NM_023079.4) - SHH439240 from Creative biogene
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UBE2Z shRNA Plasmid (Human) - CHJ2200 from Cohesion Biosciences
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UBE2Z miRNA 3'UTR clone - MiUTR3H-11834 from Creative biogene
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