OTUD7B

Gene Symbol OTUD7B
Entrez Gene 56957
Alt Symbol CEZANNE, ZA20D1
Species Human
Gene Type protein-coding
Description OTU deubiquitinase 7B
Other Description OTU domain containing 7B|OTU domain-containing protein 7B|cellular zinc finger anti-NF-kappa-B protein|cellular zinc finger anti-NF-kappaB Cezanne|zinc finger A20 domain-containing protein 1|zinc finger protein Cezanne|zinc finger, A20 domain containing 1
Swissprots D3DUZ8 Q9UFF4 Q8WWA7 Q5SZ60 B7Z643 Q6GQQ9 Q9NQ53
Accessions CAF06430 CAI12651 CAI12652 EAW53586 EAW53587 Q6GQQ9 AJ293573 CAB97494 AK299790 BAH13129 AL122102 CAB59268 BC015719 BC020622 AAH20622 BC072681 AAH72681 BP321045 BP357326 BX641079 EU446827 ABZ92356 T51077 XM_011509782 XP_011508084 XM_011509783 XP_011508085 XM_011509784 XP_011508086 XM_011509785 XP_011508087 XM_011509786 XP_011508088 XM_011509787 XP_011508089 XM_011509788 XP_011508090 NM_020205 NP_064590
Function Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'- linked polyubiquitin chains. In vitro, has preference for 'Lys- 11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin. {ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681}.
Subcellular Location Cytoplasm. Nucleus. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner.
Tissue Specificity Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells. {ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062}.

OTUD7B/Cezanne-1 Antibody - 14817 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using OTUD7B/Cezanne-1 Antibody.

OTUD7B (A-11) - sc-514334 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
OTUD7B (A-11): sc-514334. Western blot analysis of OTUD7B expression in non-transfected: sc-117752 (A) and human OTUD7B transfected: sc-370269 (B) 293T whole cell lysates.

OTUD7B (C-15) - sc-131738 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OTUD7B (C-15): sc-131738. Western blot analysis of OTUD7B expression in non-transfected: sc-117752 (A) and human OTUD7B transfected: sc-370269 (B) 293T whole cell lysates.

OTUD7B (H-4) - sc-514402 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
OTUD7B (H-4): sc-514402. Western blot analysis of OTUD7B expression in non-transfected 293T: sc-117752 (A), human OTUD7B transfected 293T: sc-370269 (B), Jurkat (C), MDA-MB-435S (D), RT-4 (E) and Hep G2 (F) whole cell lysates.

OTUD7B (F-20) - sc-102052 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
OTUD7B (F-20): sc-102052. Western blot analysis of OTUD7B expression in Jurkat whole cell lysate.

OTUD7B (N-13) - sc-131740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OTUD7B (N-13): sc-131740. Western blot analysis of OTUD7B expression in non-transfected: sc-117752 (A) and human OTUD7B transfected: sc-370269 (B) 293T whole cell lysates.

Anti-Cezanne antibody - ab118387 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-Cezanne antibody (ab118387) at 5 µg/ml + Recombinant immunogen at 0.2 µg

Anti-Cezanne antibody - ab123309 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Cezanne antibody (ab123309) at 1/100 dilution + MDA-MB453 cell line lysates at 35 µg

Anti-Cezanne antibody - ab49264 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Cezanne antibody (ab49264) at 1.25 µg/ml + Daudi cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG 1/50,000 - 1/100,000

Anti-Cezanne antibody [2B4] - ab124361 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2B4
ab124361, at 5 µg/ml, staining Cezanne in formalin fixed, paraffin embedded Human small intestine tissue by Immunohistochemistry.

Anti-OTUD7B / Cezanne Antibody (aa756-784, AP) - LS-C238584 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OTUD7B / Cezanne Antibody (aa756-784, APC) - LS-C238583 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OTUD7B / Cezanne Antibody (aa756-784, FITC) - LS-C238586 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OTUD7B / Cezanne Antibody (aa756-784, Biotin) - LS-C238585 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OTUD7B / Cezanne Antibody (aa756-784, PE) - LS-C238591 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OTUD7B / Cezanne Antibody (aa744-843) - LS-C309263 from LifeSpan Bioscience

Prices $620.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-OTUD7B / Cezanne Antibody (aa756-784, Azide-free, HRP) - LS-C248382 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OTUD7B / Cezanne Antibody (aa756-784) - LS-C329936 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OTUD7B / Cezanne Antibody (aa559-608) - LS-C31441 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Daudi Cell Lysate

Anti-OTUD7B / Cezanne Antibody (aa612-661) - LS-C109937 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
OTUD7B antibody LS-C109937 Western blot of 293T cell lysate.

Anti-OTUD7B / Cezanne Antibody (aa757-784) - LS-C163288 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
OTU7B Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-OTUD7B / Cezanne Antibody (clone 2B4) IHC-plus™ - LS-B6034 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2B4
Anti-OTUD7B antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6034 concentration 5 ug/ml.

OTUD7B/Cezanne/ZA20D1 Antibody - NBP1-88095 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OTUD7B/Cezanne/ZA20D1 Antibody [NBP1-88095] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

OTUD7B/Cezanne/ZA20D1 Antibody (2B4) - H00056957-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B4
Immunocytochemistry/Immunofluorescence: OTUD7B/Cezanne/ZA20D1 Antibody (2B4) [H00056957-M01] - Analysis of monoclonal antibody to OTUD7B on HeLa cell. Antibody concentration 10 ug/ml.

OTUD7B/Cezanne/ZA20D1 Antibody - H00056957-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: OTUD7B/Cezanne/ZA20D1 Antibody [H00056957-B01P] - Analysis of OTUD7B expression in transfected 293T cell line by OTUD7B polyclonal antibody. Lane 1: ZA20D1 transfected lysate(46.97 KDa). Lane 2: Non-transfected lysate.
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