OTUD7B
| Gene Symbol | OTUD7B |
|---|---|
| Entrez Gene | 56957 |
| Alt Symbol | CEZANNE, ZA20D1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | OTU deubiquitinase 7B |
| Other Description | OTU domain containing 7B|OTU domain-containing protein 7B|cellular zinc finger anti-NF-kappa-B protein|cellular zinc finger anti-NF-kappaB Cezanne|zinc finger A20 domain-containing protein 1|zinc finger protein Cezanne|zinc finger, A20 domain containing 1 |
| Swissprots | D3DUZ8 Q9UFF4 Q8WWA7 Q5SZ60 B7Z643 Q6GQQ9 Q9NQ53 |
| Accessions | CAF06430 CAI12651 CAI12652 EAW53586 EAW53587 Q6GQQ9 AJ293573 CAB97494 AK299790 BAH13129 AL122102 CAB59268 BC015719 BC020622 AAH20622 BC072681 AAH72681 BP321045 BP357326 BX641079 EU446827 ABZ92356 T51077 XM_011509782 XP_011508084 XM_011509783 XP_011508085 XM_011509784 XP_011508086 XM_011509785 XP_011508087 XM_011509786 XP_011508088 XM_011509787 XP_011508089 XM_011509788 XP_011508090 NM_020205 NP_064590 |
| Function | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'- linked polyubiquitin chains. In vitro, has preference for 'Lys- 11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin. {ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner. |
| Tissue Specificity | Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells. {ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062}. |
OTUD7B CRISPR/Cas9 KO Plasmid (h) - sc-403268 from Santa Cruz Biotechnology
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OTUD7B HDR Plasmid (h) - sc-403268-HDR from Santa Cruz Biotechnology
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OTUD7B Double Nickase Plasmid (h) - sc-403268-NIC from Santa Cruz Biotechnology
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OTUD7B Double Nickase Plasmid (h2) - sc-403268-NIC-2 from Santa Cruz Biotechnology
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OTUD7B CRISPR Activation Plasmid (h) - sc-403268-ACT from Santa Cruz Biotechnology
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OTUD7B CRISPR Activation Plasmid (h2) - sc-403268-ACT-2 from Santa Cruz Biotechnology
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OTUD7B Lentiviral Activation Particles (h) - sc-403268-LAC from Santa Cruz Biotechnology
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OTUD7B Lentiviral Activation Particles (h2) - sc-403268-LAC-2 from Santa Cruz Biotechnology
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OTUD7B siRNA (h) - sc-78957 from Santa Cruz Biotechnology
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OTUD7B shRNA Plasmid (h) - sc-78957-SH from Santa Cruz Biotechnology
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OTUD7B shRNA (h) Lentiviral Particles - sc-78957-V from Santa Cruz Biotechnology
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OTUD7B/Cezanne/ZA20D1 RNAi - H00056957-R01 from Novus Biologicals
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MISSION® esiRNA - EHU052501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16203 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16203 from Sigma-Aldrich
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OTUD7B siRNA (Human) - CRJ1256 from Cohesion Biosciences
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shRNA set against Human OTUD7B (NM_020205.2) - SHH369180 from Creative biogene
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shRNA set against Human OTUD7B(NM_020205.2) - SHR083724 from Creative biogene
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Human OTUD7B siRNA - orb271757 from Biorbyt
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OTUD7B shRNA Plasmid (Human) - CHJ1256 from Cohesion Biosciences
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OTUD7B miRNA 3'UTR clone - MiUTR1H-07420 from Creative biogene
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