OTUD7B

Gene Symbol	OTUD7B
Entrez Gene	56957
Alt Symbol	CEZANNE, ZA20D1
Species	Human
Gene Type	protein-coding
Description	OTU deubiquitinase 7B
Other Description	OTU domain containing 7B|OTU domain-containing protein 7B|cellular zinc finger anti-NF-kappa-B protein|cellular zinc finger anti-NF-kappaB Cezanne|zinc finger A20 domain-containing protein 1|zinc finger protein Cezanne|zinc finger, A20 domain containing 1
Swissprots	D3DUZ8 Q9UFF4 Q8WWA7 Q5SZ60 B7Z643 Q6GQQ9 Q9NQ53
Accessions	CAF06430 CAI12651 CAI12652 EAW53586 EAW53587 Q6GQQ9 AJ293573 CAB97494 AK299790 BAH13129 AL122102 CAB59268 BC015719 BC020622 AAH20622 BC072681 AAH72681 BP321045 BP357326 BX641079 EU446827 ABZ92356 T51077 XM_011509782 XP_011508084 XM_011509783 XP_011508085 XM_011509784 XP_011508086 XM_011509785 XP_011508087 XM_011509786 XP_011508088 XM_011509787 XP_011508089 XM_011509788 XP_011508090 NM_020205 NP_064590
Function	Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'- linked polyubiquitin chains. In vitro, has preference for 'Lys- 11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin. {ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner.
Tissue Specificity	Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells. {ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Cezanne full length protein - ab188704 from Abcam Category Protein Prices $572.00 Sizes 50 µg Source Baculovirus infected Sf21 cells Species Human

Human Cezanne full length protein - ab153432 from Abcam Category Protein Source Wheat germ Species Human

Human Cezanne protein fragment - ab153433 from Abcam Category Protein Source Wheat germ Species Human

OTUD7B / Cezanne Antibody Blocking Peptide - LS-E3141 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

OTUD7B / Cezanne Antibody Blocking Peptide - LS-E12290 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human OTUD7B/Cezanne/ZA20D1 Protein - H00056957-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

OTUD7B/Cezanne/ZA20D1 Partial Recombinant Protein - H00056957-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

OTU7B-Antibody-C-term-Blocking-Peptide - BP14281b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-OTUD7B/Cezanne, CF - E-562-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Contains a C-terminal 6-His tag

Recombinant Human OTUD7B/Cezanne Catalytic Domain, CF - E-563-050 from R&D Systems Category Protein Source E. coli-derived, Asn124 - Leu436

ZA20D1 - H00056957-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ZA20D1 - H00056957-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ZA20D1 - H00056957-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ZA20D1 - H00056957-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

OTUD7B fusion protein - Ag10513 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

OTUD7B fusion protein - Ag9788 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human OTUD7B, His-tagged - OTUD7B-1481H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human OTUD7B, GST-tagged - OTUD7B-1480H from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human OTU domain-containing protein 7B(OTUD7B) ,partial - CSB-YP753588HU CSB-EP753588HU CSB-BP753588HU CSB-MP753588HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human His6-OTUD7B/Cezanne Protein, CF - E-562 from R&D Systems Category Protein Prices $269.00 Sizes 50 µg Source Spodoptera frugiperda , Sf 21 (baculovirus)-derived Contains a C-terminal 6-His tag Species Human

Recombinant Human OTUD7B/Cezanne Catalytic Domain, CF - E-563 from R&D Systems Category Protein Prices $195.00 Sizes 50 µg Source E. coli -derived Asn124 - Leu436 Species Human

His6-OTUD7B/Cezanne - E-562 from Boston Biochem Prices $269.00 Sizes 50 µg

OTUD7B/Cezanne, Catalytic Domain - E-563 from Boston Biochem Prices $195.00 Sizes 50 µg

ZA20D1 - TP309932 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

OTUD7B/Cezanne/ZA20D1 Recombinant Protein Antigen - NBP1-88095PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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