| Gene Symbol |
OTUD7B
|
| Entrez Gene |
56957
|
| Alt Symbol |
CEZANNE, ZA20D1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
OTU deubiquitinase 7B
|
| Other Description |
OTU domain containing 7B|OTU domain-containing protein 7B|cellular zinc finger anti-NF-kappa-B protein|cellular zinc finger anti-NF-kappaB Cezanne|zinc finger A20 domain-containing protein 1|zinc finger protein Cezanne|zinc finger, A20 domain containing 1
|
| Swissprots |
D3DUZ8 Q9UFF4 Q8WWA7 Q5SZ60 B7Z643 Q6GQQ9 Q9NQ53
|
| Accessions |
CAF06430 CAI12651 CAI12652 EAW53586 EAW53587 Q6GQQ9 AJ293573 CAB97494 AK299790 BAH13129 AL122102 CAB59268 BC015719 BC020622 AAH20622 BC072681 AAH72681 BP321045 BP357326 BX641079 EU446827 ABZ92356 T51077 XM_011509782 XP_011508084 XM_011509783 XP_011508085 XM_011509784 XP_011508086 XM_011509785 XP_011508087 XM_011509786 XP_011508088 XM_011509787 XP_011508089 XM_011509788 XP_011508090 NM_020205 NP_064590
|
| Function |
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'- linked polyubiquitin chains. In vitro, has preference for 'Lys- 11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin. {ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner.
|
| Tissue Specificity |
Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells. {ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062}.
|