CLEC6A

Gene Symbol	CLEC6A
Entrez Gene	93978
Alt Symbol	CLEC4N, CLECSF10
Species	Human
Gene Type	protein-coding
Description	C-type lectin domain family 6, member A
Other Description	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10|C-type lectin domain family 6 member A|C-type lectin superfamily member 10|DC-associated C-type lectin 2|dectin 2|dectin-2|dendritic cell-associated C-type lectin 2
Swissprots	A2RUK3 Q6EIG7
Accessions	EAW88620 Q6EIG7 AK308011 AY321309 AAQ83725 AY365135 AAR13071 BC132933 AAI32934 BC132935 AAI32936 NM_001007033 NP_001007034
Function	Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity). {ECO:0000250}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids. {ECO:0000269|PubMed:15175046, ECO:0000269|PubMed:15368084, ECO:0000269|PubMed:15810886}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Dectin-2 (H-46) - sc-134905 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Dectin-2 (E-12) - sc-240296 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Dectin-2 (N-13) - sc-240294 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-DECTIN 2 antibody - ab68998 from Abcam Host Rabbit Clonality Polyclonal

Anti-DECTIN 2 antibody - ab79776 from Abcam Host Sheep Clonality Polyclonal

Anti-DECTIN 2 antibody - ab99181 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DECTIN 2 antibody [IMG3D1] - ab107572 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone IMG3D1

Anti-CLEC6A / Dectin 2 Antibody (Extracellular Domain, Biotin) - LS-C44828 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody (Extracellular Domain, Low Endotoxin) - LS-C44829 from LifeSpan Bioscience Prices $415.00 Sizes 500 µg Host Rat Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody (Extracellular Domain, FITC) - LS-C44830 from LifeSpan Bioscience Prices $285.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody (Extracellular Domain) - LS-C44831 from LifeSpan Bioscience Prices $280.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody (Extracellular Domain, RPE) - LS-C44832 from LifeSpan Bioscience Prices $325.00 Sizes 100 tst Host Rat Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody - LS-C94121 from LifeSpan Bioscience Prices $325.00 Sizes 500 µg Host Sheep Clonality Polyclonal

Anti-CLEC6A / Dectin 2 Antibody - LS-C94116 from LifeSpan Bioscience Prices $325.00 Sizes 500 µg Host Rabbit Clonality Polyclonal

Anti-CLEC6A / Dectin 2 Antibody (Extracellular Domain) - LS-C123385 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody (Extracellular Domain, clone D2.11E4) - LS-C123383 from LifeSpan Bioscience Prices $455.00 Sizes 250 µg Host Rat Clonality Monoclonal Clone D2.11E4

Anti-CLEC6A / Dectin 2 Antibody (Extracellular Domain) - LS-C123384 from LifeSpan Bioscience Prices $545.00 Sizes 500 µg Host Rat Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody (aa46-209) - LS-C125446 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody (aa46-209, APC) - LS-C128556 from LifeSpan Bioscience Prices $590.00 Sizes 100 tst Host Mouse Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody (aa46-209, PE) - LS-C128558 from LifeSpan Bioscience Prices $530.00 Sizes 100 tst Host Mouse Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody (aa46-209, CF) - LS-C128557 from LifeSpan Bioscience Prices $445.00 Sizes 100 tst Host Mouse Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody (Extracellular Domain, APC) - LS-C128562 from LifeSpan Bioscience Prices $605.00 Sizes 100 tst Host Goat Clonality Polyclonal

Anti-CLEC6A / Dectin 2 Antibody (Extracellular Domain, PE) - LS-C128561 from LifeSpan Bioscience Prices $435.00 Sizes 100 tst Host Rat Clonality Monoclonal

Anti-CLEC6A / Dectin 2 Antibody (aa136-163, AP) - LS-C233946 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CLEC6A / Dectin 2 Antibody (aa136-163, Biotin) - LS-C233947 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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