CLEC6A

Gene Symbol	CLEC6A
Entrez Gene	93978
Alt Symbol	CLEC4N, CLECSF10
Species	Human
Gene Type	protein-coding
Description	C-type lectin domain family 6, member A
Other Description	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10|C-type lectin domain family 6 member A|C-type lectin superfamily member 10|DC-associated C-type lectin 2|dectin 2|dectin-2|dendritic cell-associated C-type lectin 2
Swissprots	A2RUK3 Q6EIG7
Accessions	EAW88620 Q6EIG7 AK308011 AY321309 AAQ83725 AY365135 AAR13071 BC132933 AAI32934 BC132935 AAI32936 NM_001007033 NP_001007034
Function	Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity). {ECO:0000250}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids. {ECO:0000269|PubMed:15175046, ECO:0000269|PubMed:15368084, ECO:0000269|PubMed:15810886}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DECTIN 2 protein fragment - ab157028 from Abcam Category Protein Source HEK 293 cells Species Human

CLEC6A / Dectin 2 Antibody Blocking Peptide - LS-E6123 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLEC6A / Dectin 2 Antibody Blocking Peptide - LS-E16364 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLEC6A-Antibody-C-term-Blocking-Peptide - BP18742b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Dectin-2/CLEC6A, CF - 3114-DC-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Thr46-Leu209, with an N-terminal 6-His tag

Mouse CLEC4N His tag protein - orb83422 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Mouse Species Human

Human Dectin-2 protein - orb138701 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

CLEC6A Blocking Peptide - 33R-2939 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Dectin 2 Blocking Peptide - abx161078 from Abbexa Category Peptide Species Human, Mouse, Rat

CLEC6A fusion protein - Ag20695 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CLEC6A, Fc tagged - CLEC6A-8528H from Creative Biomart Category Protein Source Human Cells Species Human

Human CLEC4N / CLEC6A / Dectin-2 Protein (Fc Tag) - 10250-H01H-50 from Sino Biological Category Protein Source Human Cells Species Human

Dectin 2 Blocking Peptide - CBP3577 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Dectin-2 - pro10241 from Covalab Category Protein Source HEK 293 cells Species Mouse

Recombinant Human C-type lectin domain family 6 member A(CLEC6A) - CSB-YP738603HU CSB-EP738603HU CSB-BP738603HU CSB-MP738603HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Dectin-2/CLEC6A Protein, CF - 3114-DC from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Thr46-Leu209, with an N-terminal 6-His tag Species Human

C-type lectin domain family 6 member A (CLEC6A), Recombinant Protein - MBS1468370 from MyBioSource Category Protein Prices $910.00, $910.00, $1,135.00, $1,135.00, $1,350.00, $1,350.00, $1,805.00, $1,805.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CLEC6A Peptide, Human - M34GP03275H from Creative Peptides Category Peptide Source Synthetic. Species Human

Dectin 2, Recombinant Protein - MBS635735 from MyBioSource Category Protein Prices $710.00 Sizes 50 µg

Recombinant Mouse Dectin-2/CLEC6A Protein, CF - 1525-DC from Novus Biologicals Category Protein Prices $329.00 Sizes 50 µg

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