CLEC6A

Gene Symbol CLEC6A
Entrez Gene 93978
Alt Symbol CLEC4N, CLECSF10
Species Human
Gene Type protein-coding
Description C-type lectin domain family 6, member A
Other Description C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10|C-type lectin domain family 6 member A|C-type lectin superfamily member 10|DC-associated C-type lectin 2|dectin 2|dectin-2|dendritic cell-associated C-type lectin 2
Swissprots A2RUK3 Q6EIG7
Accessions EAW88620 Q6EIG7 AK308011 AY321309 AAQ83725 AY365135 AAR13071 BC132933 AAI32934 BC132935 AAI32936 NM_001007033 NP_001007034
Function Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids. {ECO:0000269|PubMed:15175046, ECO:0000269|PubMed:15368084, ECO:0000269|PubMed:15810886}.

Dectin-2 CRISPR/Cas9 KO Plasmid (h) - sc-417017 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-2 HDR Plasmid (h) - sc-417017-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-2 Double Nickase Plasmid (h) - sc-417017-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-2 Double Nickase Plasmid (h2) - sc-417017-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-2 CRISPR Activation Plasmid (h) - sc-417017-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-2 CRISPR Activation Plasmid (h2) - sc-417017-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-2 Lentiviral Activation Particles (h) - sc-417017-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-2 Lentiviral Activation Particles (h2) - sc-417017-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-2 siRNA (h) - sc-63278 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dectin-2 shRNA Plasmid (h) - sc-63278-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dectin-2 shRNA (h) Lentiviral Particles - sc-63278-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN6223 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6223 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CLEC6A siRNA (Human) - CRJ4231 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLEC6A - MBS8227081 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CLEC6A (NM_001007033.1) - SHH265225 from Creative biogene

Category siRNA
Species Reactivities Human

Human CLEC6A siRNA - orb274732 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLEC6A shRNA Plasmid (Human) - CHJ4231 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CLEC6A miRNA 3'UTR clone - MiUTR1H-02215 from Creative biogene

Species Reactivities Human
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