| Gene Symbol | CLEC6A |
|---|---|
| Entrez Gene | 93978 |
| Alt Symbol | CLEC4N, CLECSF10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | C-type lectin domain family 6, member A |
| Other Description | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10|C-type lectin domain family 6 member A|C-type lectin superfamily member 10|DC-associated C-type lectin 2|dectin 2|dectin-2|dendritic cell-associated C-type lectin 2 |
| Swissprots | A2RUK3 Q6EIG7 |
| Accessions | EAW88620 Q6EIG7 AK308011 AY321309 AAQ83725 AY365135 AAR13071 BC132933 AAI32934 BC132935 AAI32936 NM_001007033 NP_001007034 |
| Function | Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids. {ECO:0000269|PubMed:15175046, ECO:0000269|PubMed:15368084, ECO:0000269|PubMed:15810886}. |